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Fmoc-L-Lys(Ac)-OH
Chemical name: N-alpha-(9-fluorenylmethyloxycarbonyl)-N-epsilon-acetyl-L-lysine // Synonyms: N-epsilon-acetyl-N-alpha-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine, (2S)-6-Acetamido-2-([[(9H-fluoren-9-yl)methoxy]carbonyl]amino)hexanoic acid,N-alpha-Fmoc-N-epsilon-acetyl-L-lysine, Fmoc-Lys(Ac) -OH, Fmoc-Lys(COCH3), Fmoc-Lys(Ac), Fmoc-L-AcK, Fm
- Product code:FAA8575
- CAS No.:159766-56-0
- Formula:C23H26N2O5
- Molecular weight:410.47 g/mol
Starting at $187.50
description
Lipidated amino acids have raised interest as they are reported to improve the pharmacokinetic and pharmacologic properties of peptide APIs and other biopharmaceuticals. This acetylated Lysine represents a short “fatty” amino acid derivative suitable for activity studies.
Furthermore, the acetylation of lysine is a common posttranslational modification with many regulatory roles. As an example, the modification of histone proteins and the interaction of acetylated lysines with aromatic rings is commonly observed in transcriptionally relevant protein-protein interactions. Thus, this acetylated lysine can be used to study protein structure, interactions, and activity.
references
Effects of Lysine Acetylation in a b-Hairpin Peptide: Comparison of an Amide-π and a Cation-π Interaction; R. M. Hughes, L. M. Waters; J. Am. Chem. Soc. 2006; 128(41): 13586-13591. https://doi.org/10.1021/ja0648460.
Substrate specificity of SIRT1-catalyzed lysine Nepsilon-deacetylation reaction probed with the side chain modified Nepsilon-acetyl-lysine analogs; Bioorg. Chem. 2010; 38(1): 17-25. https://doi.org/10.1016/j.bioorg.2009.10.001.
Mechanistic studies of malonic acid-mediated in situ acylation; K. Chandra, J. N. Naoum, T. K. Roy, C. Gilon, R. B. Gerber, A. Friedler; Biopolymers 2015; 104(5): 495-505. https://doi.org/10.1002/bip.22654.
Effect of lysine methylation and acetylation on the RNA recognition and cellular uptake of Tat-derived peptides; M.-C. Liu, C.-Y. Chen, C.-H. Chiang; W.-M. Wang, R. P. Cheng; Bioorg. Med. Chem. 2016; 24(21): 5047-5051. https://doi.org/10.1016/j.bmc.2016.08.015.
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