Chemical name: (1r,4r)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid

  • Product code:FAA8635
  • CAS No.:2188242-20-6
  • Formula:C27H32N2O6
  • Molecular weight:480.56 g/mol

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This derivative can be used as constrained building block for structure activity relationship studies. Such alpha,alpha-disubstituted amino acids are widely used in peptide design because of their structure promoting effects.


Synthesis of six-membered carboyclic ring alpha,alpha-disubstituted amino acids and arginine-rich peptides to investigate the effect of ring size on the properties of the peptide; T. Kato, Y. Kita, K. Iwanari, A. Asano, M. Oba, M. Tanaka, M. Doi; Bioorg. Med. Chem. 2021; 38: 116111.

Synthesis of a series of polar, orthogonally protected, alpha,alpha-disubstituted amino acids; T. Scott Yokum, M. G. Bursavich, S. A. Piha-Paul, D. A. Hall, M. L. McLaughlin; Tetrahedron Lett. 1997; 38(23): 4013-4016.

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