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Chemical name: 4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-phenylpiperidine-4-carboxylic acid // Synonyms: Fmoc-Pip(Ph)-OH, Fmoc-4-amino-1-phenylpiperidine-4-carboxylic acid
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This derivative can be used as constrained building block for structure activity relationship studies. Such alpha,alpha-disubstituted amino acids are widely used in peptide design because of their structure promoting effects.
Synthesis of six-membered carboyclic ring alpha,alpha-disubstituted amino acids and arginine-rich peptides to investigate the effect of ring size on the properties of the peptide; T. Kato, Y. Kita, K. Iwanari, A. Asano, M. Oba, M. Tanaka, M. Doi; Bioorg. Med. Chem. 2021; 38: 116111. https://doi.org/10.1016/j.bmc.2021.116111.
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