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Fmoc-Aeg(Dde)-OH
Chemical name: (9-Fluorenylmethyloxycarbonyl)-N-(2-((1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl)amino)ethyl)glycine // Synonyms: Dde-Aeg(Fmoc), Fmoc-N-(2-Dde-aminoethyl)-glycine, Fmoc-N-(2-Dde-aminoethyl)-Gly-OH, Fmoc-N-(N-ß-Dde-aminoethyl)-Gly-OH,N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-(2-((1-(4,4-dimethyl-2,6-dioxocyclohex ylidene)ethyl)amino)ethyl)glycine, Fmoc-Aeg(Dde)
- Product code:FAA8690
- Formula:C29H32N2O6
- Molecular weight:504.58 g/mol
- Purity :min. 98%
Starting at $135.00
description
Building block for the preparation of protected PNA (Peptide Nucleic Acid) monomers. For selective Dde-cleavage please refer to this information: The best results in terms of reactivity and selectivity were achieved using a mixture of NH2OH*HCl/imidazole in NMP/CH2Cl2. After 3 h, the Dde group was cleaved cleanly while the Fmoc group was completely stable, yielding Dde-deprotected material as the only material with a quantitative yield.
This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis.
references
Full Orthogonality between Dde and Fmoc: The Direct Synthesis of PNA-Peptide Conjugates; J. J. Díaz-Mochón, L. Bialy, M. Bradley; Org. Lett. 2004, 6(7): 1127-1129; https://doi.org/10.1021/ol049905y
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