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Fmoc-L-Thr[Psi(Me,Me)Pro]-OH
Chemical name: (4S,5R)-(N-alpha-(9-Fluorenylmethyloxycarbonyl)-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid // Synonyms: (4S,5R)-3-{[(9H-fluoren-9-yl)methoxy]carbonyl}-2,2,5-trimethyl-1,3-oxazolidine-4-carboxylic acid, Fmoc-Thr[Psi(Me,Me)Pro]-OH
- Product code:FAA8695
- CAS No.:2023823-19-8
- Formula:C22H23NO5
- Molecular weight:381.43 g/mol
- Purity :min. 99%
- Enantiomeric Purity:min. 99,7%
Starting at $162.50
description
Threonine-derived Pseudoproline monomer for SPPS. This building-block can be successfully coupled with many amino-acids using modern coupling techniques avoiding the need for pseudoproline dipeptides and giving the possibility to introduce pseudoprolines in peptides containing non-natural or rare amino-acids. For coupling efficiency studies, please refer to the listed reference.
references
Scope and limitations of pseudoprolines as individual amino acids in peptide synthesis; D. A. Senko, N. D. Timofeev, I. E. Kasheverov, I. A. Ivanov; Amino Acids 2021; 53: 665-671. https://doi.org/10.1007/s00726-021-02973-1.
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