Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-Se-(4-methoxybenzyl)-L-selenocysteine // Synonyms: Fmoc-L-Sec(pMeOBzl)-OH, Fmoc-L-Sec(Pmb)-OH, Fmoc-Sec(Mob), Fmoc-L-4-methoxybenzyl selenocysteine,(2R)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-[4-methoxybenzyl)selanyl]propionic acid, Fmoc-Sec( MPM), (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)a

  • Product code:FAA8705
  • CAS No.:150308-80-8
  • Formula:C26H25NO5Se
  • Molecular weight:510.46 g/mol
  • Purity :min. 99%
  • Enantiomeric Purity:min. 99,9%

Starting at $117.00

Grouped product items
Qty Packing unit Price SKU
100 mg
250 mg
500 mg
1 g
5 g
Safety Data Sheets

Building block for the introduction of selenocysteine by SPPS. Peptides containing selenocysteine can be cleaved from the resin with simultaneous side-chain deprotection by treatment with 5% (v/v) water, 95% (v/v) trifluoroacetic acid (TFA), 0.4 M 2,2’-dithiobis(5-nitropyridine) (DTNP) for 7 min at 60 °C or 2 h at RT. See also FAA8710 Fmoc-D-Sec(Mob)-OH.


A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins; D. T. Cohen, C. Zhang, C. M. Fadzen, A. J. Mijalis, L. Hie, K. D. Johnson, Z. Shriver, O. Plante, S. J. Miller, S. L. Buchwald, B. L. Pentelute;

Nat. Chem. 2019; 11: 78-85.

Chemical synthesis of ferredoxin with 4 selenocysteine residues using a segment condensation method; T. Takei, T. Ando, T. Takao, Y. Ohnishi, G. Kurisu, M. Iwaoka, H. Hojo; Chem. Commun. 2020; 56: 14239-14242;

Reassessment of an Innovative Insulin Analogue Excludes Protracted Action yet Highlights the Distinction between External and Internal Diselenide Bridges; B. Dhayalan, Y.-S. Chen, N. B. Phillips, M. Swain, N. K. Rege, A. Mirsalehi, M. Jarosinski, F. Ismail-Beigi, N. Metanis, M. A. Weiss; Chem. Eur. J. 2020; 26(21): 4695-4700.

Copper-Mediated Selenazolidine Deprotection Enables One-Pot Chemical Synthesis of Challenging Proteins; Z. Zhao, N. Metanis; Angew. Chem. Int. Ed. 2019; 58(41): 14610-14614. 

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information about this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!