Fmoc-D-Lys(MeDmb)-OH

Chemical name: (2R)-6-{[1-(1,3-dimethyl-2,4,6-trioxo-1,3-diazinan-5-ylidene)ethyl]amino}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid

  • Product code:FAA8845
  • Formula:C29H32N4O7
  • Molecular weight:548.60 g/mol
  • Purity :min.98%
  • Enantiomeric Purity:min.99,9%

Starting at $163.80

Grouped product items
Qty Packing unit Price SKU
1 g
$163.80
FAA8845.1000
5 g
$585.00
FAA8845.5000
25 g
$2,340.00
FAA8845.9025
description

Novel Lysine building-block for SPPS bearing a new side-chain protecting-group. MeDmb is an orthogonal protecting group, stable under acidic and basic conditions used during SPPS and can be cleaved by a mild solution of 2% hydrazine hydrate in DMF and 2% hydroxylamine in DMF. The advantage of MeDmb over dimedone derivatives is the increased hydrophilicity, which should increase their solubility in a broad range of solvents, including green solvents.


references

Scope and Limitations of Barbituric and Thiobarbituric Amino Acid Derivatives as Protecting Groups for Solid-Phase Peptide Synthesis: Towards a Green Protecting Group; S. Ramkisson, H. H. Al-Rasheed, K. A. Dahlous, B. G. De La Torre, A. El-Faham, F. Albericio; Chem. Select 2021; 6(26): 6626-6630. https://doi.org/10.1002/slct.202101539


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