Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying though a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.Continue to Iris Biotech GmbHSend request to US distributor
Chemical name: L-Alanine-7-amido-4-methylcoumarin // Synonyms: (S)-2-amino-N-(4-methyl-2-oxo-2H-chromen-7-yl)propanamide, L-Alanine 4-methylcoumaryl-7-amide, Ala-7-amino-4-methylcoumarin, H-Ala-AMC, Ala-AMC
|Molecular weight:||246,27 g/mol|
HAA1200 is a fluorogenic substrate for Aminopeptidase M, which is a metalloprotease that hydrolyzes N-terminal amino acids. The substrate shows a weak fluorescence (absorption/emission ~ 330/390 nm). After enzymatic cleavage, the fluorescence of the end product (AMC) is drastically increased (absorption/emission ~ 340/440 nm). AMC combines a high fluorescence yield with a large Stokes shift and is relatively photostable.
Synthesis of a Statistically Exhaustive Fluorescent Peptide Substrate Library for Profiling Protease Specificity; J. E. Sheppeck II, H. Kar, L. Gosink, J. B. Wheatley, E. Gjerstad, S. M. Loftus, A. R. Zubiria, J. W. Janc; Bioorg. Med. Chem. Lett. 2000, 10: 2639-2642. https://doi.org/10.1016/S0960-894X(00)00545-X.
Synthesis and Fluorogenic Properties of Some 1-(Coumarin-7-yl)-4,5-dihydro-1,2,4-triazin-6(1H)-ones; M. S. Mustafa, M. M. El-Abadelah, M. S. Mubarak; Int. J. Chem. 2011, 3(4): 89-103. https://doi.org/10.5539/ijc.v3n4p89.
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries; J. L. Harris, B. J. Backes, F. Leonetti, S. Mahrus, J. A. Ellman, C. S. Craik; Proc. Natl. Acad. Sci. USA. 2000, 97(14): 7754-7759. https://doi.org/10.1073/pnas.140132697.
A Simple Fluorescent Labeling Method for Studies of Protein Oxidation, Protein Modification, and Proteolysis; A. M. Pickering, K. J. A. Davies; Free Radic Biol Med. 2012, 52(2): 239-246. https://doi.org/10.1016/j.freeradbiomed.2011.08.018.
Do you need larger quantities for your development or production?
Please send me more information about