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H-L-Phe(4-N3)-OH
Chemical name: 4-Azido-L-phenylalanine // Synonyms: H-Phe(4-N3)-OH
- Product code:HAA1850
- CAS No.:33173-53-4
- Formula:C9H10N4O2
- Molecular weight:206.20 g/mol
- Purity :min. 99%
- Enantiomeric Purity:min. 99,9%
Starting at $135.00
description
H-Phe(4-N3) is used in protein biosynthesis as unnatural amino acid for genetic code expansion. The azido-funcionality can be further utilized to cross-link various functionalities to proteins utilizing click-chemistry.
The azido-functionality is IR-active and can be used in protein active site electrostatic environment studies. Ye, Shixin; Huber, Thomas; Vogel, Reiner; Sakmar, Thomas P. Nature Chemical Biology (2009), 5(6), 397-399. DOI:10.1038/nchembio.167;
The azide-handle can also be used for protein PEGylation or attachment to antibodies using click-chemistry.
Wilding, Kristen M.; Smith, Addison K.; Wilkerson, Joshua W.; Bush, Derek B.; Knotts, Thomas A.; Bundy, Bradley C. ACS Synthetic Biology (2018), 7(2), 510-521. DOI:10.1021/acssynbio.7b00316;
Doronina, Svetlana O.; Kline, Toni Beth U.S. (2018), US 10000555 B2.
references
Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher; Mukherji, Mridul; Zhang, Zhiwen; Schultz, Peter G. Science (2003), 301(5635), 964-967. DOI:10.1126/science.1084772;
Neumann, Heinz; Wang, Kaihang; Davis, Lloyd; Garcia-Alai, Maria; Chin, Jason W. Nature (2010), 464(7287), 441-444. DOI:10.1038/nature08817;
Rovner, Alexis J.; Haimovich, Adrian D.; Katz, Spencer R.; Li, Zhe; Grome, Michael W.; Gassaway, Brandon M.;
Amiram, Miriam; Patel, Jaymin R.; Gallagher, Ryan R.; Rinehart, Jesse; et al Nature (2015), 518(7537), 89-93. DOI:10.1038/nature14095;
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