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Chemical name: Glyoxal-hydroimidazolone isomer-13C2 // Synonyms: (S)-2-amino-5-([4,5-13C2]-4-oxo-4,5-dihydro-1H-imidazol-2-ylamino)pentanoic acid
|Molecular weight:||216,21 g/mol|
Maillard Reaction Products (MRPs) are indicators for the heat treatment of food, as well as markers of nutritional quality. They also appear naturally in the human body as so-called Advanced Glycation End Products (AGEs). As such, they are indicators for body health and disease processes, including inflammation, diabetes, cancer and ageing. Consequently, AGEs gained broad attention in cosmetics, biochemistry, food, and pharmaceutical applications.
This material is supplied as a salt containing varying contents of the acid counterion. The net content of each batch is specified in the respective certificate of analysis.
Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes; N. Ahmed, R. Babaei-Jadidi, S. K. Howell, P. J. Beisswenger and P. J. Thornalley; Diabetologia 2005; 48: 1590-603. https://doi.org/10.1007/s00125-005-1810-7
Proteomic analysis of arginine adducts on glyoxal-modified ribonuclease; W. E. Cotham, T. O. Metz, P. L. Ferguson, J. W. Brock, D. J. Hinton, S. R. Thorpe, J. W. Baynes and J. M. Ames; Mol Cell Proteomics 2004; 3: 1145-53. https://doi.org/10.1074/mcp.M400002-MCP200
Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry; P. J. Thornalley, S. Battah, N. Ahmed, N. Karachalias, S. Agalou, R. Babaei-Jadidi and A. Dawnay; The Biochemical journal 2003; 375: 581-92. https://doi.org/10.1042/BJ20030763
Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to Nepsilon-carboxymethyl-lysine- and Nepsilon-(1-carboxyethyl)lysine-modified albumin; N. Ahmed, O. K. Argirov, H. S. Minhas, C. A. Cordeiro and P. J. Thornalley; The Biochemical journal 2002; 364: 1-14. https://doi.org/10.1042/bj3640001
Chromatographic assay of glycation adducts in human serum albumin glycated in vitro by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and intrinsic fluorescence; N. Ahmed and P. J. Thornalley; The Biochemical journal 2002; 364: 15-24. https://doi.org/10.1042/bj3640015
Isolation and characterization of advanced glycation end products derived from the in vitro reaction of ribose and collagen; R. G. Paul, N. C. Avery, D. A. Slatter, T. J. Sims and A. J. Bailey; The Biochemical journal 1998; 330 ( Pt 3): 1241-8. https://doi.org/10.1042/bj3301241
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