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MG-H1-d3
Chemical name: Trideuteromethylglyoxal-hydroimidazolone isomer (mixture of two diastereoisomers) // Synonyms: (S)-2-amino-5-(5-[D3]methyl-4-oxo-4,5-dihydro-1H-imidazol-2-ylamino)pentanoic acid, methylglyoxal-hydroimidazolone isomer-d3,(2S)-2-amino-5-((5-(methyl-d3)-4-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)p entanoic acid
- Product code:HAA3002
- Formula:C9H13D3N4O3
- Molecular weight:231.27 g/mol
Starting at $418.75
description
Maillard Reaction Products (MRPs) are indicators for the heat treatment of food, as well as markers of nutritional quality. They also appear naturally in the human body as so-called Advanced Glycation End Products (AGEs). As such, they are indicators for body health and disease processes, including inflammation, diabetes, cancer and ageing. Consequently, AGEs gained broad attention in cosmetics, biochemistry, food, and pharmaceutical applications.
This material is supplied as a salt containing varying contents of the acid counterion. The net content of each batch is specified in the respective certificate of analysis.
references
Isolation and identification of 5-methyl-imidazolin-4-one derivative as glyceraldehyde-derived advanced glycation end product; T. Usui, H. Watanabe and F. Hayase; Biosci Biotechnol Biochem 2006; 70: 1496-8. https://doi.org/10.1271/bbb.50584
Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry; P. J. Thornalley, S. Battah, N. Ahmed, N. Karachalias, S. Agalou, R. Babaei-Jadidi and A. Dawnay; The Biochemical journal 2003; 375: 581-92. https://doi.org/10.1042/BJ20030763
Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to Nepsilon-carboxymethyl-lysine- and Nepsilon-(1-carboxyethyl)lysine-modified albumin; N. Ahmed, O. K. Argirov, H. S. Minhas, C. A. Cordeiro and P. J. Thornalley; The Biochemical journal 2002; 364: 1-14. https://doi.org/10.1042/bj3640001
Isolation and characterization of advanced glycation end products derived from the in vitro reaction of ribose and collagen; R. G. Paul, N. C. Avery, D. A. Slatter, T. J. Sims and A. J. Bailey; The Biochemical journal 1998; 330 ( Pt 3): 1241-8. https://doi.org/10.1042/bj3301241
Detection and identification of a protein-bound imidazolone resulting from the reaction of arginine residues and methylglyoxal; T. Henle, A. W. Walter, R. Haener and H. Klostermeyer; Zeitschrift fr Lebensmittel-Untersuchung und -Forschung 1994; 199: 55-58. https://doi.org/10.1007/bf01192954
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