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Chemical name: Methylglyoxyl-derived lysine dimer-15N2 acetic acid salt // Synonyms: 1,3-bis((S)-5-[15N]amino-5-carboxypentyl)-5-methyl-1H-imidazol-3-ium acetic acid salt
|Molecular weight:||343,41 g/mol|
In MOLD two lysines are crosslinked by imidazolium, which is derived from methylglyoxal.
Imidazolium crosslinks derived from reaction of lysine with glyoxal and methylglyoxal are increased in serum proteins of uremic patients: evidence for increased oxidative stress in uremia; H. Odani, T. Shinzato, J. Usami, Y. Matsumoto, E. Brinkmann Frye, J. W. Baynes and K. Maeda; FEBS Lett 1998; 427: 381-5 . https://doi.org/10.1016/s0014-5793(98)00416-5
Protein crosslinking by the Maillard reaction: dicarbonyl-derived imidazolium crosslinks in aging and diabetes; P. Chellan and R. H. Nagaraj; Archives of biochemistry and biophysics 1999; 368: 98-104. https://doi.org/10.1006/abbi.1999.1291
Protein cross-linking by the Maillard reaction. Isolation, characterization, and in vivo detection of a lysine-lysine cross-link derived from methylglyoxal; R. H. Nagaraj, I. N. Shipanova and F. M. Faust; J Biol Chem 1996; 271: 19338-45. https://doi.org/10.1074/jbc.271.32.19338
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