Chemical name: 5-Fluoro-6-chloro-L-tryptophan // Synonyms: (S)-2-amino-3-(5-fluoro-6-chloroindolyl)propionic acid, (S)-2-amino-3-(5-fluoro-6-chloro-1H-indol-3-yl)propionic acid, H-Trp(5-F,6-Cl)-OH

  • Product code:HAA8900
  • Formula:C11H10ClFN2O2
  • Molecular weight:256.66 g/mol

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Effect of Variation of the Strength of the Aromatic Interactions of Tryptophan on the Cooperative Structural Refolding Behavior of a Peptide from HIV 1. Simon Schweizer, Jennifer Reed; Biophysical Journal 2008; 95(7): 3381-3390. DOI: org/10.1529/biophysj.107.126375

Suche nach einem n-Hal-Trp in einer Peptidstruktur:

WO 2019246386 (Cyclic polypeptides for PCSK9 inhibition. Alonso Ricardo, Nicholas Cedric Boyer, Joseph R. Stringer, Derek M. Laplaca, Ketki Ashok Dhamnaskar, Zhong Ma, Jonathan C. Blain, Rohit Vyasamneni; Ra Pharmaceuticals Inc., USA 2019)

Interaction of tryptophan-​modified analogs of cholecystokinin-​octapeptide with cholecystokinin receptors on pancreatic acini. Hideki Adachi, Hubertus M. Rajh, Tesser, I. Godefridus, Jan Joep H. H. M. De Pont, Robert T. Jensen, Jerry D. Gardner; Biochimica et Biophysica Acta, General Subjects 1981; 678(3): 358-63. DOI: 10.1016/0304-4165(81)90115-X

Synthesis of a tritiated human growth hormone releasing peptide. Arthur Y. L. Shu, J. Richard Heys; International Journal of Peptide & Protein Research 1993; 42(5): 432-9.

Structure-​based design of potent linear peptide inhibitors of the YAP-​TEAD protein-​protein interaction derived from the YAP omega-​loop sequence.

Pascal Furet, Bahaa Salem, Yannick Mesrouze, Tobias Schmelzle, Ian Lewis, Joerg Kallen, Patrick Chene; Bioorganic & Medicinal Chemistry Letters 2019; 29(16): 2316-2319. DOI: 10.1016/j.bmcl.2019.06.022

Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C-​C Bond Coupling. Zhengyan Guo, Pengwei Li, Guozhu Chen, Chao Li, Zhenju Cao, Yuwei Zhang, Jinwei Ren, Hua Xiang, Shuangjun, Ju, Jianhua Lin, Yihua Chen; J. Am. Chem. Soc. 2018; 140(51): 18009-18015. DOI: 10.1021/jacs.8b10136

WO 2018208954 (Preparation of p53-​based peptidomimetic macrocycles as inhibitors of the p53-​MDM2, p53-​MDMX, or both p53 and MDM2 and MDMX protein-​protein interactions useful in treatment of cancers. Manuel Aivado, Vincent Guerlavais, Karen Olson; Aileron Therapeutics, Inc., USA 2018)

WO 2016154058 (Preparation of peptidomimetic macrocycles useful in treatment of liquid tumors.

Hubert Chen, David Allen Annis, Yong Chang, Manuel Aivado, Karen Olson, Chris J. Viau; Aileron Therapeutics, Inc., USA 2016)

WO 2016049355 (Peptidomimetic macrocycles and formulations thereof. David Allen Annis,; Krzysztof Darlak,; Chris Rhodes, Sonoko Kanai, Joerg Hoernschemeyer, Michaela Grass; Aileron Therapeutics, Inc., USA 2016)

WO 2013123266 (Peptidomimetic macrocycles as therapeutic agents for the treatment of disease, such as cancer. Vincent Guerlavais, Carl Elkin, Huw M. Nash, Tomi K. Sawyer, Bradford J. Graves, Eric Feyfant; Aileron Therapeutics, Inc., USA 2013)

US 20130210745 (Preparation of triazole-​crosslinked and thioether-​crosslinked p53 peptidomimetic macrocycles as inhibitors of the p53-​MDM2, p53-​MDMX, or both p53 and MDM2 and MDMX protein-​protein interactions useful in treatment of cancers and other diseases. Vincent Guerlavais, Christopher R. Conlee, Scott Paul Lentini; Aileron Therapeutics, Inc., USA 2013)

An Ultrahigh Affinity d-Peptide Antagonist Of MDM2. Changyou Zhan, Le Zhao, Xiaoli Wei, Xueji Wu, Xishan Chen, Weirong Yuan, Wei-Yue Lu, Marzena Pazgier, Wuyuan Lu; J. Med. Chem. 2012; 55(13): 6237-6241. DOI: org/10.1021/jm3005465

WO 2017165299 (Companion diagnostic tool for peptidomimetic macrocycles. Manuel Aivado; Aileron Therapeutics, Inc., USA 2017)

Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition. Michael M. Madden, Avinash Muppidi, Zhenyu Li, Xiaolong Li, Jiandong Chen, Qing Lin; Bioorganic & Medicinal Chemistry Letters 2011; 21(5): 1472-1475. DOI: org/10.1016/j.bmcl.2011.01.004

WO 2011060832 (Preparation of template-​fixed β-​hairpin peptidomimetics as CCR10 antagonists. Francoise Jung, Frank Otto Gombert, Daniel Obrecht, Christian Bisang, Sophie Barthelemy, Alexander Lederer, Eric Chevalier. Polyphor AG, Switz. 2011)

Proteomic Analysis Provides Insights on Venom Processing in Conus textile. Lemmuel L. Tayo, Bingwen Lu, Lourdes J. Cruz, John R. Yates; J. Proteome Res. 2010; 9(5): 2292-2301. DOI:


WO 2010015287 (Preparation of template-​fixed β-​hairpin peptidomimetics as urotensin II receptor agonists​/antagonists and inhibitors of the STAT6​/NCoA-​1 interaction. John Anthony Robinson, Kerstin Moehle, Markus Seitz, Ludovic T. Maillard, Roba Mounme, Frank Otto Gombert, Odile Sellier-Kessler, Heiko Henze, Daniel Obrecht, Christian Bisang, Alexander Lederer; Polyphor AG, Switz.; Universitaet Zuerich 2010)

Thermodynamic and Computational Studies on the Binding of p53‐Derived Peptides and Peptidomimetic Inhibitors to HDM2. Anja Grässlin, Celine Amoreira, Kim K. Baldridge, John A. Robinson; ChemBioChem 2009: 10(8): 1360-136. https://doi.org/10.1002/cbic.200900008

WO 2009046198 (Sustained delivery of compstatin analogs from gels. Cedric Francois, Pascal Deschatelets, Paul Olson; Potentia Pharmaceuticals, Inc., USA 2009)

The central valine concept provides an entry in a new class of non peptide inhibitors of the p53–MDM2 interaction. Pascal Furet, Patrick Chène, Alain De Pover, Thérèse Stachyra Valat, Joanna Hergovich Lisztwan, Joerg Kallen, Keiichi Masuya; Bioorganic & Medicinal Chemistry Letters 2012; 22(10): 3498-3502. DOI: org/10.1016/j.bmcl.2012.03.083

The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction.

Screening for post-translational modifications in conotoxins using liquid chromatography/mass spectrometry: an important component of conotoxin discovery. Jennifer A. Jakubowski, Wayne P. Kelley, Jonathan V. Sweedler; Toxicon 2006; 47(6): 688-699. DOI: org/10.1016/j.toxicon.2006.01.021

Structure–Activity Studies in a Family of β‐Hairpin Protein Epitope Mimetic Inhibitors of the p53–HDM2 Protein–Protein Interaction. Rudi Fasan, Ricardo L. A. Dias, Kerstin Moehle, Oliver Zerbe, Daniel Obrecht, Peer R. E. Mittl, Markus G. Grütter, John A. Robinson; ChemBioChem 2006; 7(3): 515-526. DOI: org/10.1002/cbic.200500452

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