H-L-Cys(DMNB)-OH

Chemical name: S-(4,5-dimethoxy-2-nitrobenzyl)-L-cysteine // Synonyms: S-[(4,5-Dimethoxy-2-nitrophenyl)methyl]-L-cysteine

  • Product code:HAA9320
  • CAS No.:214633-68-8
  • Formula:C12H16N2O6S
  • Molecular weight:316.33 g/mol
  • Purity :min.99%

Starting at $250.90

Grouped product items
Qty Packing unit Price SKU
100 mg
$250.90
HAA9320.0100
250 mg
$418.60
HAA9320.0250
500 mg
$754.00
HAA9320.0500
1 g
$1,170.00
HAA9320.1000
description

This building-block permits incorporation of a photocaged cysteine in a protein. The caging group is removed by UV light leaving the cysteine in place.


references

A method for directed evolution and functional cloning of enzymes; H. Pedersen, S. Hölder, D. P. Sutherlin, U. Schwitter, D. S. King, P. G. Schultz; PNAS 1998; 95(18): 10523-10528. https://doi.org/10.1073/pnas.95.18.10523

Light Activation of Protein Splicing with a Photocaged Fast Intein; W. Ren, A. Ji. H.-W. Ai; J. Am. Chem. Soc. 2015; 137(6): 2155-2158. https://doi.org/10.1021/ja508597d

Light-Activation of DNA-Methyltransferases; J. Wolffgramm, B. Buchmuller, S. Palei, A. Muñoz-López, J. Kanne, P. Janning, M. R. Schweiger, D. Summerer; Angew. Chem. Int. Ed. 2021; 60(24): 13507-13512. https://doi.org/10.1002/anie.202103945

Biosynthetic selenoproteins with genetically-encoded photocaged selenocysteines; R. Rakauskaitė, G. Urbanavičiūtė, A. Rukšėnaitė, Z. Liutkevičiūtė, R. Juškėnas, V. Masevičius, S. Klimašauskas; Chem. Commun. 2015; 51: 8245-8248. https://doi.org/10.1039/C4CC07910H


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