NucleoPEP Library

Chemical name: Library of carbohydrate&nucleoside-peptide conjugates (0.1µmol of 237 compounds in three micro titer plates)

Art-No.:LIBG003
Grouped product items
Product variant
1 Kit
$7,425.00
LIBG003.0001
description
The N-terminal cleavage product of human insulin-like growth factor-1 (IGF-1) in the brain is the tripeptide molecule (Gly-Pro-Glu). Many other analogues have been discovered to show in-vitro and in-vivo activities in the areas of neuroprotective effects of brain injury, are in clinical trials for the prevention of cognitive impairment following cardiac surgery, or reduce the injury size in rats subjected to focal stroke. (Gly-L-Pro-L-Glu) on the cytotox ic action of A 1-42 were tested with differentiated human neuroblastoma SH-SY5Y cells as cellular Alzheimer model via measurements of mitochondrial viability (MTT assay) and lactate dehydrogenase release (LDH assay).

references
Reference:

NNZ-2566: A Gly-Pro-Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke. M. J. Bickerdike, G. B. Thomas, D. C. Batchelor, E. S. Sirimanne, W. Leong, H. Lin, F. Sieg, J. Wen, M. A. Brimble, P. W. Harris and P. D. Gluckman; Journal of the Neurological Sciences 2009; 278: 85-90. DOI: 10.1016/j.jns.2008.12.003

A three amino acid peptide, Gly-Pro-Arg, protects and rescues cell death induced by amyloid -peptide. M. Ioudina and E. Uemura; Experimental Neurology 2003; 184: 923-929. DOI: 10.1016/S0014-4886(03)00314-5

(R)--Lipoyl-Gly-L-Pro-L-Glu dimethyl ester as dual acting agent for the treatment of Alzheimers disease. L. Marinelli, E. Fornasari, A. Di Stefano, H. Turkez, M. E. Arslan, P. Eusepi, M. Ciulla and I. Cacciatore; Neuropeptides 2017; 66: 52-58. DOI: .org/10.1016/j.npep.2017.09.001

Development of glycine--methyl-proline-containing tripeptides with neuroprotective properties. I. Cacciatore, E. Fornasari, A. Di Stefano, L. Marinelli, L. S. Cerasa, H. Turkez, E. Aydin, A. Moretto, A. Ferrone, M. Pesce, V. di Giacomo, M. Reale, E. Costantini, P. Di Giovanni, L. Speranza, M. Felaco and A. Patruno; European Journal of Medicinal Chemistry 2016; 108: 553-563.

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