Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying though a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.Continue to Iris Biotech GmbHSend request to US distributor
Semi-synthetic derivate of Geldanamycin (LS-1031)
Benzoquinone ansamycin antibiotic. Geldamycin is among other things used to cure cancer patients. It specifically ties up to the heat shock protein 90 (HSP 90) and inhibits its function. Binding of Geldamycin to HSP 90 causes the decomposition of target-proteins such as Tyrosin kinases, Steroid receptors, Transcription factors and cell-cycle involved kinases. It induces the inactivation, destabilisation and finally the decomposition of cancer related proteins like v-Src, Bcr-Abl, p53 or HIF-1a. An extremely interesting research reagent for the biotechnology industry.
Fukuyo, Y. et al., Geldanamycin and its anti-cancer activities. Cancer Lett. 2010; 290(1):24-35.
Miyata, Y., Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents. Curr Pharm Des. 2005; 11(9):1131-8.
Do you need larger quantities for your development or production?
Please send me more information about