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Chemical name: 5-(methylamino)-2-[[(2S,3R,5R,8S,9S)-3,5,9-trimethyl-2-[1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid // Synonyms: 4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-((3,9,11-trimethyl-8-(1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)-1,7-dioxaspiro(5.5)undec-2-yl)methyl)-, (6S-(6alpha(2S*,3S*),8beta(R*),9beta,11alpha))-, A23187 (free acid), Calcimycin, Calcium Ionophore A23187
|Molecular weight:||523,63 g/mol|
Antibiotic properties against gram positive bacteria and fungi. Ionophore for divalent cations, esp. Mn2+, Ca2+ & Mg2+. Allowing these Ions to pass cell membranes and thus uncoupling oxidative phosphorylation.
Abbott, B.J. et al., Microbial transformation of A23187, a divalent cation ionophore antibiotic. Antimicrobial Agents and Chemotherapy 1979, 16 (6): 808-812.
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