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Aphidicolin
Chemical name: (+)-Aphidicolin
- Product code:LS-1011
- CAS No.:38966-21-1
- Formula:C20H34O4
- Molecular weight:338,49 g/mol
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description
Tetracyclic diterpene antibiotic with antiviral, antineoplastic and antimitotic properties. It is a reversible inhibitor of eukaryotic nuclear DNA replication and blocks the cell cycle at early S phase. Furthermore it is known as a specific inhibitor of DNA polymerase A,D in eukaryotic cells and in some viruses. Aphidicolin belongs to the group of
mycotoxins.
references
Nigrospora oryzae. Spadari, S. et al. Control of cell division by aphidicolin without adverse effects upon resting cells. Arzneimittelforschung. 1985; 35(7):1108-16.
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