Aphidicolin

Chemical name: (+)-Aphidicolin

  • Product code:LS-1011
  • CAS No.:38966-21-1
  • Formula:C20H34O4
  • Molecular weight:338,49 g/mol
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description

Tetracyclic diterpene antibiotic with antiviral, antineoplastic and antimitotic properties. It is a reversible inhibitor of eukaryotic nuclear DNA replication and blocks the cell cycle at early S phase. Furthermore it is known as a specific inhibitor of DNA polymerase A,D in eukaryotic cells and in some viruses. Aphidicolin belongs to the group of

mycotoxins.

references

Nigrospora oryzae. Spadari, S. et al. Control of cell division by aphidicolin without adverse effects upon resting cells. Arzneimittelforschung. 1985; 35(7):1108-16.

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