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Ascomycin
Synonyms: FK520
- Product code:LS-1012
- CAS No.:104987-12-4 and 11011-38-4
- Formula:C43H69NO12
- Molecular weight:792.03 g/mol
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description
Strong immunosuppressant; inhibits allogenic T-lymphocyte proliferation. It binds with high affinity to FKBP and inhibits calcineurin phosphatase in the nM range; ethyl analog of FK506; .
references
1. Arai, T. et al. (1962) J. Antibiot. (Tokyo). 15, 231.
2. Morisaki, M. et al. (1992) J. Antibiot. (Tokyo). 45, 126.
3. Meadows, R.P. et al. (1993) Biochemistry. 32, 754.
4. Yu, L. et al. (1994) J. Magn. Reson. B. 104, 77.
5. Kawai, M. et al. (1998) Bioorg. Med. Chem. Lett. 8, 935.
6. Plath, K.E. et al. (2003) Clin. Exp. Allergy. 33, 342.
7. Paul, C. et al. (2000) Expert Opin. Investig. Drugs. 9, 69.
8. Griffiths, C.E. (2001) Br. J. Dermatol. 144, 679.
9. Wellington, K. et al. (2002) Drugs. 62, 817.
10. Quatresooz, P. et al. (2003) Rev. Med. Liege. 58, 168.
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