Alamethicin

Synonyms: Antibiotic U-22324, Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phenylalaninol

  • Product code:LS-1075
  • CAS No.:27061-78-5
  • Formula:C92H150N22O25
  • Molecular weight:1964.3 g/mol

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description

Alpha-helical peptide antibiotic produced by the fungus Trichoderma viride. It forms tetra- and hexameric voltage gated ion channels in membranes and can mimic nerve action potential across artificial membrandes.


references

Fox, R.O. Jr, Richards, F.M., A voltage-gated ion channel model inferred from the crystal structure of alamethicin at 1.5-A resolution. Nature. 1982; 300(5890):325-30.

Mathew, M.K., Balaram P., Alamethicin and related membrane channel forming polypeptides. Mol Cell Biochem. 1983; 50(1):47-64.

Stella, L., et al., Alamethicin interaction with lipid membranes: a spectroscopic study on synthetic analogues. Chem Biodivers. 2007; 4(6):1299-312.

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