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TT-232-Biotin diacetate
Chemical name: H-D-Phe-Cys-Tyr-D-Trp-Lys(Biotin)-Cys-Thr-NH2 (disulfide bridged) // Synonyms: CAP-232-Biotin, TLN-232-Biotin, TT-232-Biotin, TT 232-Biotin, TT232-Biotin; TT-232-Biotin
- Product code:LS-1522
- Formula:C55H72N12O11S3 (net)
- Molecular weight:1173.43 (net) g/mol
Starting at $803.40
description
TT-232 is a structural analogue of somatostatin, a hormone with significant, selective antiproliferative, anti-inflammatory and antisecretory properties. In contrast to the parent hormone and its “traditional” analogues, this compound has strong and specific growth-inhibitory potential without the wide-ranging endocrine side-effects, including inhibition of insulin secretion provoking diabetes. Its mechanism of action is in line with the so-called signal-transduction therapy, where "internal communication" of cells is corrected without interfering with basic cell functions and machinery. Moreover, TT-232 acts on pyruvate kinase translocation and neurogenic inflammation. In vitro and in vivo studies show a selective antitumor activity with induction of strong apoptosis of cancer cells.
references
Evaluation of the Antitumor Efficacy of the Somatostatin Structural Derivative TT-232 on Different Tumor Models; M. Tejeda, D. Gaál, L. Hullán, B. Hegymegi-Barakonyi, G. Kéri; Anticancer Res. 2006; 26: 3477-83.
A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity; G. Kéri, J. Erchegyi, A. Horváth, I. Mezõ, M. Idei, T. Vántus, A. Balogh, Z. Vadász, G. Bökönyi, J. Seprõdi, I. Teplán, O. Csuka, M. Tejeda, D. Gaál, Z. Szegedi, B. Szende, C. Roze, H. Kalthoff, A. Ullrich; Proc. Natl. Acad. Sci. U. S. A. 1996; 93: 12513-12518. https://doi.org/10.1073/pnas.93.22.12513
Inhibitory Effects of Synthetic Somatostatin Receptor Subtype 4 Agonists on Acute and Chronic Airway Inflammation and Hyperreactivity in the Mouse; K. Elekes, Z. Helyes, L. Kereskai, K. Sándor, E. Pintér, G. Pozsgai, V. Tékus, A. Bánvölgyi, J. Németh, T. Szuts, G. Kéri, J. Szolcsányi; Eur. J. Pharmacol. 2008; 578: 313-22. https://doi.org/10.1016/j.ejphar.2007.09.033
Inhibitory Effect of Peptide Mimetics Including Naphthyl Group on DNA Polymerase b Activity; A. Miyazaki, R. Ito, A. Enomoto, Y. Tsuda, I. Kuriyama, H. Yoshida, Y. Mizushina; Peptide Science 2013; 49: 201-202.
Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver; Y. Jung, S.-H. Oh, R. P. Witek, B. E. Petersen; Liver International 2011; 32: 312-320. https://doi.org/10.1111/j.1478-3231.2011.02642.x
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