Bestatin HCl

Chemical name: N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine hydrochloride

Product code:LS-3880
CAS No.:65391-42-6
Formula:C16H24N2O4 * HCl
Molecular weight:308,38*36,45 g/mol
Grouped product items
Qty Packing unit Price SKU
25 mg
$236.25
LS-3880.0025
500 mg
$1,336.50
LS-3880.0500
1000 mg
$1,687.50
LS-3880.1000
5000 mg
$6,412.50
LS-3880.5000
New
description

Reversible inhibitor of aminopeptidase enzymes. Shows no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or thermolysin.


references

Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool; A. Trochine, D. J. Creek, P. Faral-Tello, M. P. Barrett and C. Robello; Antimicrob Agents Chemother 2015; 59: 2921-5. doi:10.1128/AAC.05046-14

Enhanced anticancer activity of 5-FU in combination with Bestatin: Evidence in human tumor-derived cell lines and an H22 tumor-bearing mouse; J. Li, X. Wang, J. Hou, Y. Huang, Y. Zhang and W. Xu; Drug discoveries & therapeutics 2015; 9: 45-52. doi:10.5582/ddt.2015.01006

Proteasome inhibitors reconstitute the presentation of cytotoxic T-cell epitopes in Epstein-Barr virus-associated tumors; R. Gavioli, S. Vertuani and M. G. Masucci; Int J Cancer 2002; 101: 532-8. doi:10.1002/ijc.10653

The aminopeptidase activity in the human T-cell lymphoma line (Jurkat) is not at the cell surface and is not aminopeptidase N (CD-13); H. Murray, A. J. Turner and A. J. Kenny; Biochem J 1994; 298 ( Pt 2): 353-60.

Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells; A. Menrad, D. Speicher, J. Wacker and M. Herlyn; Cancer Res 1993; 53: 1450-5.

Aminopeptidase activity of an antitumor antibiotic, C-1027; N. Sakata, K. S. Tsuchiya, Y. Moriya, H. Hayashi, M. Hori, T. Otani, M. Nagai and T. Aoyagi; The Journal of antibiotics 1992; 45: 113-7.

Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes; H. Umezawa, T. Aoyagi, H. Suda, M. Hamada and T. Takeuchi; The Journal of antibiotics 1976; 29: 97-9.


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