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Reversible inhibitor of aminopeptidase enzymes. Shows no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or thermolysin.
Bestatin induces specific changes in Trypanosoma cruzi dipeptide pool; A. Trochine, D. J. Creek, P. Faral-Tello, M. P. Barrett and C. Robello; Antimicrob Agents Chemother 2015; 59: 2921-5. doi:10.1128/AAC.05046-14
Enhanced anticancer activity of 5-FU in combination with Bestatin: Evidence in human tumor-derived cell lines and an H22 tumor-bearing mouse; J. Li, X. Wang, J. Hou, Y. Huang, Y. Zhang and W. Xu; Drug discoveries & therapeutics 2015; 9: 45-52. doi:10.5582/ddt.2015.01006
Proteasome inhibitors reconstitute the presentation of cytotoxic T-cell epitopes in Epstein-Barr virus-associated tumors; R. Gavioli, S. Vertuani and M. G. Masucci; Int J Cancer 2002; 101: 532-8. doi:10.1002/ijc.10653
The aminopeptidase activity in the human T-cell lymphoma line (Jurkat) is not at the cell surface and is not aminopeptidase N (CD-13); H. Murray, A. J. Turner and A. J. Kenny; Biochem J 1994; 298 ( Pt 2): 353-60.
Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells; A. Menrad, D. Speicher, J. Wacker and M. Herlyn; Cancer Res 1993; 53: 1450-5.
Aminopeptidase activity of an antitumor antibiotic, C-1027; N. Sakata, K. S. Tsuchiya, Y. Moriya, H. Hayashi, M. Hori, T. Otani, M. Nagai and T. Aoyagi; The Journal of antibiotics 1992; 45: 113-7.
Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes; H. Umezawa, T. Aoyagi, H. Suda, M. Hamada and T. Takeuchi; The Journal of antibiotics 1976; 29: 97-9.
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