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Chemical name: [3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid] // Synonyms: Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-L-val-L-val-statinyl-L-alastatine
|Molecular weight:||685,90 g/mol|
against thiol proteases.
Potential targets: Pepsin, Renin, Cathepsin D, Chymosin, Protease B, retroviral Proteases
Alves, L. Castro, F. Baltazar, S. R. Chaves, A. Preto and M. Corte-Real; Cell death & disease 2015; 6: e1788. doi:10.1038/cddis.2015.157
Inhibitory effects of pepstatin A and mefloquine on the growth of Babesia parasites; T. Munkhjargal, M. AbouLaila, M. A. Terkawi, T. Sivakumar, M. Ichikawa, B. Davaasuren, T.
Nyamjargal, N. Yokoyama and I. Igarashi; Am J Trop Med Hyg 2012; 87: 681-8. doi:10.4269/ajtmh.2012.12-0218
Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion; Y. Liu, Y. Zhou and K. Zhu; PLoS One 2012; 7: e45910. doi:10.1371/journal.pone.0045910
A Multifunctional Protease Inhibitor To Regulate Endolysosomal Function; S. I. van Kasteren, I. Berlin, J. D. Colbert, D. Keane, H. Ovaa and C. Watts; ACS Chemical Biology 2011;
6: 1198-1204. doi:10.1021/cb200292c
Induction of cell death in neuroblastoma by inhibition of cathepsins B and L; R. Colella, G. Lu, L. Glazewski, B. Korant, A. Matlapudi, M. R. England, C. Craft, C. N. Frantz and
R. W. Mason; Cancer Lett 2010; 294: 195-203. doi:10.1016/j.canlet.2010.01.037
Pepstatin, a new pepsin inhibitor produced by Actinomycetes; H. Umezawa, T. Aoyagi, H. Morishima, M. Matsuzaki and M. Hamada; The Journal of antibiotics 1970; 23: 259-62.
T. Munkhjargal, M. AbouLaila, M. A. Terkawi, T. Sivakumar, M. Ichikawa, B. Davaasuren, T. Nyamjargal, N. Yokoyama, and I. Igarashi(2012) Inhibitory Effects of Pepstatin A and
Mefloquine on the Growth of Babesia Parasites. Am. J. Trop. Med. Hyg., 87(4), 681-688.
H. Umezawa, T. Aoyagi, H. Morishima, M. Matsuzaki, M. Hamada. (1970) Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo), 23(5), 25962.
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