Chemical name: (3aS,4S,6aR)-N-[3-(11,12-Didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide // Synonyms: Biotin-Dibenzocyclooctyne

  • Product code:LS-4270
  • CAS No.:1418217-95-4
  • Formula:C28H30N4O3S
  • Molecular weight:502.63 g/mol

Starting at $520.00

Grouped product items
Qty Packing unit Price SKU
100 mg
250 mg

This biotin derivative bears a terminal DBCO group. It can be used to prepare various biotinylated conjugates via Click Chemistry. Biotin can be subsequently detected e.g. via streptavidin or avidin. DBCO alkynes allow to perform click reactions with azide-modified targets without the use of heavy metal catalysis via a strain-promoted azide-alkyne click reaction (SPAAC).


High-Throughput “FP-Tag” Assay for the Identification of Glycosyltransferase Inhibitors; Z. Gao, O. G. Ovchinnikova, B.-S. Huang, F. Liu, D. E. Williams, R. J. Andersen, T. L. Lowary, C. Whitfield, S. G. Withers; J. Am. Chem. Soc. 2019; 141(6): 2201-2204.

Site-Specific Dual Functionalization of Cysteine Residue in Peptides and Proteins with 2-Azidoacrylates; S. Ariyasu, H. Hayashi, B. Xing, S. Chiba; Bioconjugate Chem. 2017; 28(4): 897-902.

Diazo Groups Endure Metabolism and Enable Chemoselectivity in Cellulo; K. A. Andersen, M. R. Aronoff, N. A. McGrath, R. T. Raines; J. Am. Chem. Soc. 2015; 137(7): 2412-2415.

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information about this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!