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Chemical name: N-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)-1-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-3,6,9,12-tetraoxapentadecan-15-amide
|Molecular weight:||674,82 g/mol|
This biotin derivative bears a terminal methyltetrazine group. It can be used to prepare various biotinylated conjugates. Biotin can be subsequently detected e.g. via streptavidin or avidin. The methyltetrazine is reactive to trans-cyclooctenes. The PEG linker improves the overall solubility of the derivative.
A Sweet Galactose Transfer: Metabolic Oligosaccharide Engineering as a Tool to Study Glycans in Plasmodium Infection; A. Kitowski, G. J. L. Bernardes; ChemBioChem 2020; 21(18): 2696-2700. https://doi.org/10.1002/cbic.202000226.
A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level; A. Rutkowska, D. W. Thomson, J. Vappiani, T. Werner, K. M. Mueller, L. Dittus, J. Krause, M. Muelbaier, G. Bergamini, M. Bantscheff; ACS Chem. Biol. 2016; 11(9): 2541-2550. https://doi.org/10.1021/acschembio.6b00346.
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