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This biotin derivative bears a terminal alkyne group. It can be used to prepare various biotinylated conjugates via Click Chemistry. Biotin can be subsequently detected e.g. via streptavidin or avidin.
New Serie of BPL Inhibitors To Probe the Ribose-Binding Pocket of Staphylococcus aureus Biotin Protein Ligase; J. Feng, A. S. Paparella, W. Tieu, D. Heim, S. Clark, A. Hayes, G. W. Booker, S. W. Polyak, A. D. Abell; ACS Med. Chem. Lett. 2016; 7(12): 1068-1072. https://doi.org/10.1021/acsmedchemlett.6b00248.
Heterocyclic acyl-phosphate-bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase; W. Tieu, A. M. Jarrad, A. S. Paparella, K. A. Keeling, T. P. Soares da Costa, J. C. Wallace, G. W. Booker, S. W. Polyak, A. D. Abell; Bioorg. Med. Chem. Lett. 2014; 24(19): 4689-4693. https://doi.org/10.1016/j.bmcl.2014.08.030.
Optimising in situ click chemistry: the screening and identification of biotinprotein ligase inhibitors; W. Tieu, T. P. Soares da Costa, M. Y. Yap, K. L. Keeling, M. C. J. Wilce, J. C. Wallace, G. W. Booker, S. W. Polyak, A. D. Abell; Chem. Sci. 2013; 4: 3533-3537. https://doi.org/10.1039/C3SC51127H.
Biotin Analogues with Antibacterial Activity Are Potent Inhibitors of Biotin Protein Ligase; T. P. Soares da Costa, W. Tieu, M. Y. Yap, O. Zvarec, J. M. Bell, J. D. Turnidge, J. C. Wallace, G. W. Booker, M. C. J. Wilce, A. D. Abell, S. W. Polyak; ACS Med. Chem. Lett. 2012; 3(6): 509-514. https://doi.org/10.1021/ml300106p.
Selective inhibition of biotin protein ligase from Staphylococcus aureus; T. P. Soares da Costa; W. Tieu, M. Y. Yap, N. R. Pendini, S. W. Polyak, D. S. Pedersen, R. Morona, J. D. Turnidge, J. C. Wallace; M. C. J. Wilce, G. W. Booker, A. D. Abell; J. Biol. Chem. 2012; 287(21): 17823-17832. https://doi.org/10.1074/jbc.M112.356576.
Molecular Recognition Studies on Naphthyridine Derivatives; J. C. Iglesias-Sánchez, D. Santa Maria, R. M. Claramunt, J. Eluero; Molecules 2010; 15(3): 1213-1222. https://doi.org/10.3390/molecules15031213.
Synthesis of a Biotin-Derived Alkyne for Pd-Catalyzed Coupling Reactions; C. Corona, B. K. Bryant, J. B. Arterburn; Org. Lett. 2006; 8(9): 1883-1886. https://doi.org/10.1021/ol060458r.
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