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Fmoc-L-Ala-MPPA
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-alanine-3-(4-oxymethylphenoxy)propionic acid // Synonyms: 3-(4-((((((9H-fluoren-9-yl)methoxy)carbonyl)alanyl)oxy)methyl)phenoxy)propanoic acid, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-alanine-[4-(2-carboxyethoxy)phenyl]methyl ester,Fmoc-Ala-MPPA
- Product code:LW00102
- CAS No.:864876-89-1
- Formula:C28H27NO7
- Molecular weight:489.52 g/mol
Starting at $97.50
description
This Fmoc-amino acid-MPPA linker serves as precursor for the linkage to e.g. aminomethyl supports by standard coupling procedures. By this method, a low (max 0.5%) and reproducible epimerization level of the C-terminal amino acid in your peptide is guaranteed.
references
Improved approach for anchoring Nalpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis; F. Albericio, G. Barany; Int. J. Peptide. Protein. Res. 1985; 26(1): 92-97. https://doi.org/10.1111/j.1399-3011.1985.tb03182.x.
Amino acid derivatives used as agents bonding to a solid support; NeoMPS S.A. 2005; French Patent Application FR 0402973, International Patent Application WO2005/095332.
A peptide hydrogel derived from a fragment of human cardiac troponin C; L. M. De Leon-Rodriguez, M. Kamalov, Y. Hemar, A. K. Mitra, V. Castelletto, D. Hermida-Merino, I. W. Hamley, M. A. Brimble; Chem. Commun. 2016; 52: 4056-4059. https://doi.org/10.1039/C6CC00209A.
Solid phase oxime ligations for the iterative synthesis of polypeptide conjugates; I. E. Decostaire, D. Lelièvre, V. Aucagne, A. F. Delmas; Org. Biomol. Chem. 2014; 12: 5536-5543. https://doi.org/10.1039/C4OB00760C.
An improved procedure for the preparation of aminomethyl polystyrene resin and its use in solid phase (peptide) synthesis; P. W. R. Harris, S. Hyun Yang, M. A. Brimble; Tetrahedron Lett. 2011; 52(45): 6024-6026. https://doi.org/10.1016/j.tetlet.2011.09.010.
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