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Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-leucine-3-(4-oxymethylphenoxy)propionic acid // Synonyms: 3-(4-((((((9H-fluoren-9-yl)methoxy)carbonyl)-L-leucyl)oxy)methyl)phenoxy)propanoic acid, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine-[4-(2-carboxyethoxy)phenyl]methyl ester
|Molecular weight:||531,61 g/mol|
This Fmoc-amino acid-MPPA linker serves as precursor for the linkage to e.g. aminomethyl supports by standard coupling procedures. By this method, a low (max 0.5%) and reproducible epimerization level of the C-terminal amino acid in your peptide is guaranteed.
Improved approach for anchoring Nalpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis; F. Albericio, G. Barany; Int. J. Peptide. Protein. Res. 1985; 26(1): 92-97. https://doi.org/10.1111/j.1399-3011.1985.tb03182.x.
Amino acid derivatives used as agents bonding to a solid support; NeoMPS S.A. 2005; French Patent Application FR 0402973, International Patent Application WO2005/095332.
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