Mal-L-Dap(Boc)-OH*DCHA

Chemical name: N-alpha-MaleimidoN-beta-t-butyloxycarbonyl-L-2,3-diaminopropionic acid dicyclohexylamine // Synonyms: Mal-Dap(Boc)*DCHA, Mal-Dpr(Boc)*DCHA CAS 1491152-23-8 net

Product code:MAA1040
CAS No.:2004724-16-5
Formula:C12H16N2O6*C12H23N
Molecular weight:284,27*181,32 g/mol
Grouped product items
Qty Packing unit Price SKU
250 mg
$108.00
MAA1040.0250
500 mg
$194.40
MAA1040.0500
1 g
$302.40
MAA1040.0001
5 g
$1,080.00
MAA1040.0005
25 g
$4,320.00
MAA1040.0025
Safety Data Sheets
description

Building block, which can be used for conjugation with thiol groups. After removal of the Boc protecting group and conjugation with the mercaptane function the free methylamino side chain will open the maleimide ring under aqueous conditions. While the conjugation reaction between thiol and maleimid is reversible, it turns completely stable in the open ring structure. This becomes particularly important in the formation of conjugates with high value components, like in antibody-drug conjugation (ADC).

references

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates; R.P. Lyon, J.R. Setter, T.D. Bovee, S.O. Doronia, J.H. Hunter, M.E.

Anderson, C.L.Balasubramanian, S.M. Duniho, C.I. Leiske, F. Li, P.D. Senter; Nature Biotechnology. 2014; 32(10): 1059-1062. Doi:10.1038/nbt.2968.

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