Name: Mal-L-Dap(Boc)-OH*DCHA
SKU: MAA1040
Availability: InStock

Grouped product items

Qty

Packing unit

Price

SKU

250 mg

$100.00

MAA1040.0250

500 mg

$180.00

MAA1040.0500

1 g

$280.00

MAA1040.0001

5 g

$1,000.00

MAA1040.0005

25 g

$4,000.00

MAA1040.0025

Safety Data Sheets

description

Building block, which can be used for conjugation with thiol groups. After removal of the Boc protecting group and conjugation with the mercaptane function the free methylamino side chain will open the maleimide ring under aqueous conditions. While the conjugation reaction between thiol and maleimid is reversible, it turns completely stable in the open ring structure. This becomes particularly important in the formation of conjugates with high value components, like in antibody-drug conjugation (ADC).

references

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates; R.P. Lyon, J.R. Setter, T.D. Bovee, S.O. Doronia, J.H. Hunter, M.E.

Anderson, C.L.Balasubramanian, S.M. Duniho, C.I. Leiske, F. Li, P.D. Senter; Nature Biotechnology. 2014; 32(10): 1059-1062. Doi:10.1038/nbt.2968.