New

Mal-L-Dap(Boc)-OH

Chemical name: N-alpha-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-6-((9-fluorenylmethyloxycarbonyl)amino)hexyl)-L-alanine // Synonyms: Fmoc-Ddax-Ala, Fmoc-Ddax-Ala-OH, (2S)-2-{[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-6-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexyl]amino}propanoic acid

Product code:MAA1041
CAS No.:1491152-23-8
Formula:C12H16N2O6
Molecular weight:284,27 g/mol
Grouped product items
Qty Packing unit Price SKU
100 mg
$116.10
MAA1041.0100
250 mg
$194.40
MAA1041.0250
500 mg
$349.65
MAA1041.0500
1 g
$544.05
MAA1041.1000
5 g
$1,944.00
MAA1041.5000
description

Mal-Dap(Boc) is used as building block, which can be used for conjugation with thiol groups. After removal of the Boc protecting group and conjugation with the mercaptane function the free methylamino side chain will open the maleimide ring under aqueous conditions. While the conjugation reaction between thiol and maleimide is reversible, it turns completely stable in the open ring structure. This becomes particularly important in the formation of conjugates with high value components, like in antibody-drug conjugation (ADC).


references

Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics; R. Lyon, P. Burke, J. Hunter; PCT Int. Appl. 2015; WO 2015057699 A2.


Antibody-drug conjugates of tubulysin analogs with enhanced stability; Q. Cong, S. Gangwar, V. S. Rangan, M.-C. Sung; PCT Int. Appl. 2017; WO 2017196598 A1.


Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates; R. P. Lyon, J. R. Setter, T. D. Bovee, S. O. Doronina, J. H. Hunter, M. E. Anderson, C. L. Balasubramanian, S. M. Duniho, C. I. Leiske, F. Li, and P. D. Senter; Nat. Biotechnol. 2014; 32; 1059-1062. https://doi.org/10.1038/nbt.2968

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information of this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!
Structure image for Fmoc-L-Dap(Z)-OH
Fmoc-L-Dap(Z)-OH

Starting at $60.75

Structure image for Fmoc-D-Dap(Mtt)-OH
Fmoc-D-Dap(Mtt)-OH

Starting at $133.65

Structure image for Fmoc-L-Dap(Mtt)-OH
Fmoc-L-Dap(Mtt)-OH

Starting at $121.50

Structure image for Fmoc-L-Dap(Dde)-OH
Fmoc-L-Dap(Dde)-OH

Starting at $97.20

Structure image for Z-L-Dap-OH
Z-L-Dap-OH

Starting at $101.25

Structure image for Fmoc-L-Dap(Fmoc)-OH
Fmoc-L-Dap(Fmoc)-OH

Starting at $101.25

Structure image for Fmoc-L-Agp(Boc)2-OH
Fmoc-L-Agp(Boc)2-OH

Starting at $108.00

Structure image for Fmoc-L-Dap(Dnp)-OH
Fmoc-L-Dap(Dnp)-OH

Starting at $135.00

Structure image for Z-D-Dap-OH
Z-D-Dap-OH

Starting at Please inquire

Structure image for Fmoc-L-Dap(ivDde)-OH
Fmoc-L-Dap(ivDde)-OH

Starting at $109.35

Structure image for Fmoc-D-Dap(Dde)-OH
Fmoc-D-Dap(Dde)-OH

Starting at $133.65

Structure image for Fmoc-D-Dap(ivDde)-OH
Fmoc-D-Dap(ivDde)-OH

Starting at $145.80

Structure image for Fmoc-D-Dap(Z)-OH
Fmoc-D-Dap(Z)-OH

Starting at $114.75

Structure image for Fmoc-D-Agp(Boc)2-OH
Fmoc-D-Agp(Boc)2-OH

Starting at $162.00

Structure image for Trt-L-Dap(Fmoc)-OH
Trt-L-Dap(Fmoc)-OH

Starting at Please inquire

Structure image for Trt-D-Dap(Fmoc)-OH
Trt-D-Dap(Fmoc)-OH

Starting at Please inquire

Structure image for Z-L-Dap(Aloc)-OH*DCHA
Z-L-Dap(Aloc)-OH*DCHA

Starting at $74.25

Structure image for Z-L-Dap(Boc)-OH
Z-L-Dap(Boc)-OH

Starting at $168.75

Structure image for Z-L-Dap(Fmoc)-OH
Z-L-Dap(Fmoc)-OH

Starting at $67.50

Structure image for Z-D-Dap(Boc)-OH
Z-D-Dap(Boc)-OH

Starting at $101.25

Structure image for Z-D-Dap(Fmoc)-OH
Z-D-Dap(Fmoc)-OH

Starting at $101.25

Structure image for Fmoc-D-Dap(Fmoc)-OH
Fmoc-D-Dap(Fmoc)-OH

Starting at $168.75

Structure image for Fmoc-L-Dap(Octanoyl)-OH
Fmoc-L-Dap(Octanoyl)-OH

Starting at $113.40

Structure image for Fmoc-L-Dap(Palm)-OH
Fmoc-L-Dap(Palm)-OH

Starting at $113.40

Structure image for Z-L-Dap-OMe*HCl
Z-L-Dap-OMe*HCl

Starting at $135.00

Structure image for Z-D-Dap-OMe*HCl
Z-D-Dap-OMe*HCl

Starting at $121.50

Structure image for Fmoc-L-Mim-OH
Fmoc-L-Mim-OH

Starting at $2,025.00

Structure image for Fmoc-D-Dap(Dnp)-OH
Fmoc-D-Dap(Dnp)-OH

Starting at Please inquire

Structure image for Fmoc-L-Dap(Teoc)-OH
Fmoc-L-Dap(Teoc)-OH

Starting at Please inquire

Structure image for Z-L-Dap(N3)-OH
Z-L-Dap(N3)-OH

Starting at $97.20

Structure image for Fmoc-D-Dap(octanoyl)-OH
Fmoc-D-Dap(octanoyl)-OH

Starting at $135.00

Structure image for Fmoc-D-Dap(Palm)-OH
Fmoc-D-Dap(Palm)-OH

Starting at $135.00

Structure image for Fmoc-L-Dap(Ns)-OH
Fmoc-L-Dap(Ns)-OH

Starting at $108.00

Structure image for Fmoc-D-Dap(Ns)-OH
Fmoc-D-Dap(Ns)-OH

Starting at $121.50

Structure image for Fmoc-L-Ala(N-Pyrr)-OH
Fmoc-L-Ala(N-Pyrr)-OH

Starting at $243.00