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Mal-L-Dap(Boc)-OPfp
Chemical name: N-alpha-MaleimidoN-beta-t-butyloxycarbonyl-L-2,3-diaminopropionic acid pentafluorophenolate // Synonyms: Mal-Dap(Boc)-OPfp, Mal-Dpr(Boc)-OPfp, 2,3,4,5,6-pentafluorophenyl (2S)-3-{[(tert-butoxy)carbonyl]amino}-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate
- Product code:MAA1080
- CAS No.:1887132-90-2
- Formula:C18H15F5N2O6
- Molecular weight:450.31 g/mol
- Purity :min. 98%
- Enantiomeric Purity:min. 99,7%
Starting at $123.50
description
Mal-Dap(Boc)-OPfp is used in drug conjugate construction leading to more stable conjugates due to Dap neighboring-group assistance. This strategy is widely used in antibody-drug conjugation (ADC).
references
Lyon, Robert; Burke, Patrick; Hunter, Joshua; PCT Int. Appl. (2015), WO 2015057699 A2;
Cong, Qiang; Gangwar, Sanjeev; Rangan, Vangipuram S.; Sung, Mei-Chen; PCT Int. Appl. (2017), WO 2017196598 A1;
Burke, Patrick J.; Courter, Joel; PCT Int. Appl. (2017), WO 2017096311 A1.
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