Mal-L-Dap(Boc)-OPfp

Chemical name: N-alpha-MaleimidoN-beta-t-butyloxycarbonyl-L-2,3-diaminopropionic acid pentafluorophenolate // Synonyms: Mal-Dap(Boc)-OPfp, Mal-Dpr(Boc)-OPfp, 2,3,4,5,6-pentafluorophenyl (2S)-3-{[(tert-butoxy)carbonyl]amino}-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoate

Product code:MAA1080
CAS No.:1887132-90-2
Formula:C18H15F5N2O6
Molecular weight:450,31 g/mol
Grouped product items
Qty Packing unit Price SKU
250 mg
$128.25
MAA1080.0250
500 mg
$229.50
MAA1080.0500
1 g
$357.75
MAA1080.1000
5 g
$1,282.50
MAA1080.5000
25 g
$5,130.00
MAA1080.9025
Safety Data Sheets
New
description

Mal-Dap(Boc)-OPfp is used in drug conjugate construction leading to more stable conjugates due to Dap neighboring-group assistance. This strategy is widely used in antibody-drug conjugation (ADC).

references

Lyon, Robert; Burke, Patrick; Hunter, Joshua; PCT Int. Appl. (2015), WO 2015057699 A2;

Cong, Qiang; Gangwar, Sanjeev; Rangan, Vangipuram S.; Sung, Mei-Chen; PCT Int. Appl. (2017), WO 2017196598 A1;

Burke, Patrick J.; Courter, Joel; PCT Int. Appl. (2017), WO 2017096311 A1.


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