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Mal-AMCHC-N-Propargylamide
Chemical name: trans-4-[(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]-N-(prop-2-yn-1-yl)cyclohexane-1-carboxamide // Synonyms: MCC-Yne, SMCC Propargyl amide, Maleimido-AMCHC-Propargylamide, Mal-AMCHC-N-Propynyl
- Product code:MAA1100
- CAS No.:2027476-42-0
- Formula:C15H18N2O3
- Molecular weight:274.32 g/mol
- Purity :min. 98%
Starting at $156.00
description
Related CAS number: 1036847-90-1 of the (cis,trans) stereoisomer mixture.
Used as a bio-conjugation reagent for antibody-drug-conjugate synthesis using Click-Chemistry.
references
Antibody Conjugates of 7-Ethyl-10-hydroxycamptothecin (SN-38) for Targeted Cancer Chemotherapy. Sung-Ju Moon, Serengulam V. Govindan, Thomas M. Cardillo, Christopher A. D’Souza, Hans J. Hansen, David M. Goldenberg; J. Med. Chem. 2008; 51(21): 6916-6926. DOI: 10.1021/jm800719t
WO2019154120A1
US20160303253A1
US20170360770A1
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