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Mal-L-Dap(Boc)-OSu
Chemical name: N-alpha-Maleimido-N-beta-Boc-L-2,3-diaminopropionic acid NHS ester // Synonyms: Mal-Dap(Boc)-NHS, Mal-Dpr(Boc)-Osu, Mal-Dpr(Boc)-NHS, (S)-maleoyl-DPR(boc)-OSu, (S)-maleoyl-DPR(boc)-NHS, 2,5-dioxopyrrolidin-1-yl(2S)-3-{[(tert-butoxy)carbonyl]amino}-2-(2,5-dioxo-2,5-dihydro-1H-py rrol-1-yl)propanoate, Mal-Dap(Boc)-Osu
- Product code:MAA1120
- CAS No.:1703778-79-3
- Formula:C16H19N3O8
- Molecular weight:381.34 g/mol
- Purity :min.98%
- Enantiomeric Purity:min.99,7%
Starting at $120.00
description
Mal-Dap(Boc)-OSu is used in drug conjugate construction leading to more stable conjugates due to Dap neighbouring-group assistance. This strategy is widely used by Seagen Inc. and others.
references
PCT Int. Appl. (2015), WO 2015057699 A2
PCT Int. Appl. (2017), WO 2017196598 A1
PCT Int. Appl. (2020), WO2020132655 A1
PCT Int. Appl. (2021), WO2021207701 A1
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