I-PEG-N3 (20 kDa)

Chemical name: alpha-Iodo-omega-azido poly(ethylene glycol) (PEG-MW 20000 Dalton) // Synonyms: I-PEG(20 kDa)-N3

Product code:PEG3140
Molecular weight:20000 Da
Grouped product items
Qty Packing unit Price SKU
100 mg
$364.50
PEG3140.0100
500 mg
$985.50
PEG3140.0500
Safety Data Sheets
description

In conjugation techniques with thiol groups from Cystein or other SH carrying moieties normally maleimides are used, which react also with other acid protons like for example from OH or NH2 and give appropriate unwanted impurities. The Iodo group reacts much more specifically with thiol resulting in much cleaner conjugates.

references

Quantitative reactivity profiling predicts functional cysteins in proteomes; K.Weerapana, C.Wang, G.M.Simon, F.Richter, S.Khare, M.B.D.Dillon, D.A.Bachovichin, K.Mowen, D.Baker,

B.J.Cravatt; Nature 2010; 468: 790-795.

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