CLICK CHEMISTRY

CLICK CHEMISTRY

Alkynes and azides can undergo a Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC; 1st Generation Click Chemistry) to afford 1,4-disubstituted 1,2,3-triazoles. Developed by K. Barry Sharpless and Morton Meldal, this type of chemical transformation was quickly dubbed “Click Chemistry”. As alternative, the so-called strain-promoted azide-alkyne cycloaddition (SPAAC; 2nd Generation Click Chemistry) is widely utilized as copper-free click reaction. Besides, tetrazine ligation represents the option for a copper-free, rapid, and fully biorthogonal type of Click Chemistry based on an inverse electron-demand Diels-Alder (IEDDA; 3rd Generation Click Chemistry) cycloaddition reaction between a tetrazine and a strained alkene.
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  1. Structure image for Halo-DBCO
    Halo-DBCO

    Product code: RL-3670

  2. Structure image for Halo-PEG(5)-azide
    Halo-PEG(5)-azide

    Product code: RL-3640

  3. Structure image for Biotin-N3
    Biotin-N3

    Product code: LS-4210

  4. Structure image for Biotin-DBCO
    Biotin-DBCO

    Product code: LS-4270

  5. Structure image for Biotin-MeTz
    Biotin-MeTz

    Product code: LS-4280

  6. Structure image for TCEP*HCl
    TCEP*HCl

    Product code: LS-3405

  7. Structure image for DBCO-SNAP
    DBCO-SNAP

    Product code: RL-4010

  8. Structure image for alpha-GalNAc-TEG-N3
    alpha-GalNAc-TEG-N3

    Product code: GBB1370

  9. Structure image for beta-Gal-TEG-Alkyne
    beta-Gal-TEG-Alkyne

    Product code: GBB1385

  10. Structure image for beta-Glc-N3
    beta-Glc-N3

    Product code: GBB1435

  11. Structure image for beta-Glc-TEG-N3
    beta-Glc-TEG-N3

    Product code: GBB1390

  12. Structure image for beta-GlcNAc-N3
    beta-GlcNAc-N3

    Product code: GBB1450

  13. Structure image for beta-Glc-TEG-Alkyne
    beta-Glc-TEG-Alkyne

    Product code: GBB1395

  14. Structure image for beta-Lac-TEG-N3
    beta-Lac-TEG-N3

    Product code: GBB1410

  15. Structure image for beta-Lac-TEG-Alkyne
    beta-Lac-TEG-Alkyne

    Product code: GBB1415

  16. Structure image for ICG-alkyne
    ICG-alkyne

    Product code: RL-2880

  17. Structure image for ICG-DBCO
    ICG-DBCO

    Product code: RL-2870

  18. Structure image for ICG-azide
    ICG-azide

    Product code: RL-2840

  19. Structure image for ICG-Tz
    ICG-Tz

    Product code: RL-2860

  20. Structure image for Prg-PGA(20)
    Prg-PGA(20)

    Product code: PGA1085

  21. Structure image for Prg-PGA(50)
    Prg-PGA(50)

    Product code: PGA1090

  22. Structure image for Prg-PGA(100)
    Prg-PGA(100)

    Product code: PGA1095

  23. Structure image for Prg-PGA(200)
    Prg-PGA(200)

    Product code: PGA1100

  24. Structure image for N3-PGA(20)
    N3-PGA(20)

    Product code: PGA1125

  25. Structure image for N3-PGA(50)
    N3-PGA(50)

    Product code: PGA1130

  26. N3-PGA(100)
    N3-PGA(100)

    Product code: PGA1135

  27. Structure image for N3-PGA(200)
    N3-PGA(200)

    Product code: PGA1140

  28. Structure image for nBu-PGA(20)[Prg(20)]
    nBu-PGA(20)[Prg(20)]

    Product code: PGA1190

  29. Structure image for nBu-PGA(50)[Prg(20)]
    nBu-PGA(50)[Prg(20)]

    Product code: PGA1195

  30. Structure image for nBu-PGA(100)[Prg(20)]
    nBu-PGA(100)[Prg(20)]

    Product code: PGA1200

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