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Carbohydrates for Click Chemistry
Glycosylation is the most complex posttranslational modification and can be observed on membrane proteins, secreted proteins and peptides, or proteins in the cytosol and nucleus. Synthetic glycoconjugates are interesting targets for the investigation of immunogenicity, infection pathways or structure activity relationships, and for the development of novel drugs and vaccines. Carbohydrates functionalized for Click chemistry provide mild and selective access to glycoconjugates.
