Trityl/TCP Resins

Trityl/TCP Resins

Resins functionalized with trityl linkers are highly acid sensitive, as the three phenyl rings stabilize the benzylic carbocation that is generated during cleavage. These cleavage conditions are so mild that only 1% of TFA is needed, and even less acidic protocols using 20% hexafluoroisopropanol (HFIP) are sufficient to cleave the products from the resin. Various trityl-based linkers exist with different substitutions on the trityl group that fine-tune the cleavage conditions and stability of the preloaded resin.