Wang/Benzylalcohol Resins

Wang/Benzylalcohol Resins

The Wang resin might at first glance look very similar to the original Merrifield resin, but the cleavage conditions are significantly milder (50% (v/v) TFA in DCM) due to the alkoxy group of the para alkoxybenzyl alcohol linker. These mild cleavage conditions made the Wang resin popular not only in the peptide field, but also among organic chemists in general, as it can also be used to attach e.g. phenols and alcohols.