H-L-Cys(Clt)-2CT Resin

Chemical name: H-L-Cys(Clt)-2-chlorotrityl resin

Product code:RAA1050
Particle size :100-200 mesh
DVB crosslinking :1% DVB
Loading:> 0.4 mmol/g
Grouped product items
Qty Packing unit Price SKU
5 g
$229.50
RAA1050.0005
25 g
$904.50
RAA1050.0025
description

The Clt (2-chlorotrityl) protecting group is more stable than the commonly used Trt group and is best deprotected by oxidative methods with Iodine resulting in a simultaneous disulfide bridge formation. It is therefore best used in the synthesis of cyclic peptides with several disulfide bridges in particular for the synthesis of the second S-S bridge.

references

Aletras A., Barlos K. et al; Int. J. Pept. Protein Res. 1995; 45(5): 488-496.

Barlos K. et al; Int. J. Pept. Protein Res. 1991; 38(6): 555-561.

Sarah L.M. et al, in „Fmoc Solid Phase Synthesis. A practical approach“, Ed.: Chan W.C., White P.D. Oxford University Press 2000, page 177.

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