H-L-His(Clt)-2CT Resin

Chemical name: H-L-His(Clt)-2-chlorotrityl resin // Synonyms: H-His(Clt)-2CT Resin

  • Product code:RAA1093
  • Particle size :100-200 mesh
  • DVB crosslinking :1% DVB
  • Loading:> 0.4 mmol/g

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Qty Packing unit Price SKU
Please inquire Please inquire Please inquire RAA1093.0000
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description

The Clt (2-chlorotrityl) protecting group is more stable than the commonly used Trt group and is being deprotected with 95%TFA in dichloromethane. The main application is in peptide synthesis, whenever certain treatments and modifications of the peptide are being applied, where the standard His(Trt) protection is too labile.

references

Aletras A., Barlos K. et al; Int. J. Pept. Protein Res. 1995; 45(5): 488-496.

Barlos K. et al; Int. J. Pept. Protein Res. 1991; 38(6): 555-561.

Sarah L.M. et al, in „Fmoc Solid Phase Synthesis. A practical approach“, Ed.: Chan W.C., White P.D. Oxford University Press 2000, page 177.

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