PyAOP

Chemical name: (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinyl-phosphorus hexafluorophosphate // Synonyms: (1H-7-Azabenzotriazole-1-yl)-oxy-tris-pyrrolidino-phosphonium hexafluorophosphat

Product code:RL-1210
CAS No.:156311-83-0
Formula:C17H27N7OP*PF6
Molecular weight:376,42*144,96 g/mol
Grouped product items
Qty Packing unit Price SKU
25 g
$162.00
RL-1210.0025
100 g
$472.50
RL-1210.0100
500 g
$1,890.00
RL-1210.0500
Safety Data Sheets
description

Coupling reagent for peptide synthesis, disulfide bond engineering, and heteroaryl ether synthesis. Optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain.

Applications reported for the synthesis of cyclic RGC pentapeptides with functionalization through click chemistry.

references

A Practical Large-Scale Synthesis of Cyclic RGD Pentapeptides Suitable for Further Functionalization through ‘Click’ Chemistry; J. Palecek, G. Dräger and A. Kirschning; Synthesis

2011; 2011: 653-661. doi:10.1055/s-0030-1258396

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing; C. F. Carter, H. Lange, S. V. Ley, I. R. Baxendale, B. Wittkamp, J. G. Goode and N. L. Gaunt;

Organic Process Research & Development 2010; 14: 393-404. doi:10.1021/op900305v

Development of Fluorescent Glucose Bioprobes and Their Application on Real-Time and Quantitative Monitoring of Glucose Uptake in Living Cells; H. Y. Lee, J. J. Lee, J. Park and S.

B. Park; Chemistry - A European Journal 2011; 17: 143-150. doi:10.1002/chem.201002560

Modulating Oxytocin Activity and Plasma Stability by Disulfide Bond Engineering; M. Muttenthaler, A. Andersson, A. D. de Araujo, Z. Dekan, R. J. Lewis and P. F. Alewood; Journal

of Medicinal Chemistry 2010; 53: 8585-8596. doi:10.1021/jm100989w

Heteroaryl Ethers by Oxidative Palladium Catalysis of Pyridotriazol-1-yloxy Pyrimidines with Arylboronic Acids; S. Bardhan, S. Wacharasindhu, Z.-K. Wan and T. S. Mansour; Organic

Letters 2009; 11: 2511-2514. doi:10.1021/ol900592b

Global optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain; Y.-Q. Long, F.-D. T. Lung and P. P. Roller; Bioorganic &

Medicinal Chemistry 2003; 11: 3929-3936. doi:http://dx.doi.org/10.1016/S0968-0896(03)00411-5

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