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Chemical name: Methyltetrazine-PEG(4)-maleimide // Synonyms: 3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-(2-(2-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethyl)propanamide, 2,?5-?dihydro-?N-?[2-?[2-?[2-?[2-?[4-?(6-?methyl-?1,?2,?4,?5-?tetrazin-?3-?yl)?phenoxy]?ethoxy]?ethoxy]?ethoxy]?ethyl]?-?2,?5-?dioxo-1H-?Pyrrole-?1-?propanamide
|Molecular weight:||514,53 g/mol|
Activated tetrazine maleimide cross-linker with enhaced solubility due to the PEG moiety, used for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with dienophiles, and addition to free thiols.
Bioorthogonal labelling of biomolecules: new functional handles and ligation methods; Marjoke F. Debets, Jan C. M. van Hest and Floris P. J. T. Rutjes; Org. Biomol. Chem. 2013; 11: 6439-6455; DOI: 10.1039/c3ob41329b.
Biomedical Applications of Tetrazine Cycloadditions; Neal K. Devaraj and Ralph Weissleder; Acc. Chem. Res. 2011; 44(9): 816-827. DOI: 10.1021/ar200037t.
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