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Chemical name: Methyltetrazine-PEG(4)-BisSulfon-Thiol-Linker // Synonyms: 1-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)-15-oxo-20-(4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoyl)-3,6,9,12-tetraoxa-16,20-diazatricosane-23-sulfonic acid
|Molecular weight:||1097,28 g/mol|
Unique cross-linker for azid function bearing compounds integrating into existing disulfide bonds, eg. from enzymes or antibodies, maintaining the structural properties of the biomolecule.
Bioorthogonal labelling of biomolecules: new functional handles and ligation methods; Marjoke F. Debets, Jan C. M. van Hest and Floris P. J. T. Rutjes; Org. Biomol. Chem. 2013; 11: 6439-6455; DOI: 10.1039/c3ob41329b.
Biomedical Applications of Tetrazine Cycloadditions; Neal K. Devaraj and Ralph Weissleder; Acc. Chem. Res. 2011; 44(9): 816-827. DOI: 10.1021/ar200037t.
Site-Directed Chemical Modification and Cross-Linking of a Monoclonal Antibody Using Equilibrium Transfer Alkylating Cross-Link Reagents; Frederick A. Liberatore, Robert D. Comeau, James M. McKearin, Daniel A. Pearson, Benjamin Q. Belonfa III, Stephen J. Brocchini, John Kath, Terri Phillips, Kira Oswell, and Richard G. Lawton A; Bioconjugate Chem. 1990; 7: 36-50.
Sulfhydryl Site-Specific Cross-Linking and Labeling of Monoclonal Antibodies by a Fluorescent Equilibrium Transfer Alkylation Cross-Link Reagent; Renato B. del Rosario, Richard L. Wahl, Stephen J. Brocchini, Richard G. Lawton, and Richard H. Smith; Bioconjugate Chem. 1990; 1: 51-59.
Streptavidin-biotinylated IgG Conjugates: a Simple Procedure for Reducing Polymer Formation; Renato B. Del Rosario, Lee Ann Baron; Richard G. Lawton and Richard L. Wahl; Nucl. Med. Biol. 1992; 19(3): 417-421.
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