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MeTz-PEG(4)-NH2*HCl
Chemical name: Methyltetrazine-PEG(4)-amine HCL salt // Synonyms: 2-(2-(2-(2-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy)ethoxy)ethoxy)ethoxy)ethanamine HCl salt
- Product code:RL-2370
- CAS No.:1802908-05-9 net
- Formula:C17H25N5O4*HCl
- Molecular weight:363.41*HCl g/mol
Starting at $286.00
description
New three-functional clickable cross-linker, which shows superior thermal stability compared to DIBAC and other cyclooctyne based ring systems. DACN also shows high specifity and does not undergo side reactions with thiols (eg. from cysteines) as it has been observed with cyclooctyne derivatives and other constrained ring systems.
references
2‑Aminobenzenesulfonamide-Containing Cyclononyne as Adjustable Click Reagent for Strain-Promoted Azide−Alkyne Cycloaddition; Kyosuke Kaneda, Risa Naruse, and Syota Yamamoto; Org. Lett. 2017; 19(5): 1096–1099. DOI: 10.1021/acs.orglett.7b00123
Heteroatom-embedded Medium-Sized Cycloalkynes: Concise Synthesis, Structural Analysis, and Reactions; Runyan Ni, Naoto Mitsuda, Takeru Kashiwagi, Kazunobu Igawa, and Katsuhiko Tomooka; Angew. Chem. Int. Ed. 2015; 54: 1190-1194. DOI: 10.1002/anie.201409910.
A Strain-Promoted [3 + 2] Azide-Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems; Nicholas J. Agard, Jennifer A. Prescher, and Carolyn R. Bertozzi; J. Am. Chem. Soc. 2004; 126: 15046-15047. DOI: 10.1021/ja044996f.
Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry; Julian A. Codelli, Jeremy M. Baskin, Nicholas J. Agard, and
Carolyn R. Bertozzi; J. Am. Chem. Soc. 2008; 130: 11486–11493; DOI: 10.1021/ja803086r.
Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition; Marjoke F. Debets, Sander S. van Berkel, Sanne Schoffelen, Floris P. J. T. Rutjes, Jan C. M. van Hest and Floris L. van Delft; Chem. Commun. 2010; 46: 97. DOI: 10.1039/b917797c
Preventing Thiol-Yne Addition Improves the Specificity of Strain-Promoted Azide−Alkyne Cycloaddition; Remon van Geel, Ger J. M. Pruijn, Floris L. van Delft, and Wilbert C. Boelens; Bioconjugate Chem. 2012; 23: 392. dx.doi.org/10.1021/bc200365k.
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