DBCO-COOH

Chemical name: Dibenzoazacyclooctyne-carboxylic acid // Synonyms: DBCO-C6-acid, ADIBO-acid, Azadibenzocyclooctyne-carboxylic acid, 6-oxo-6-(azadibenzocyclooctyn-1-yl)hexanoic acid

Product code:RL-2430
CAS No.:1425485-72-8
Formula:C21H19NO3
Molecular weight:333,38 g/mol
Grouped product items
Qty Packing unit Price SKU
100 mg
$432.00
RL-2430.0100
1000 mg
$2,200.50
RL-2430.1000
description

Cyclooctyne linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with azides and tetrazines. The carboxylic acid function can be used to form amid bonds with amines.

references

Simon et al.; Facile Double-Functionalization of Designed Ankyrin Repeat Proteins using Click and Thiol Chemistries. Bioconjugate Chem. 2012; 23(2): 279.

Zeng et al.; 64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Nano. 2012; 6(6): 5209.

Arumugam et al.; [18F]Azadibenzocyclooctyne ([18F]ADIBO): A biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg. Med. Chem.

Lett. 2011; 21: 6987.

Campbell-Verduyn et al.; Strain-Promoted Copper-Free Click Chemistry for 18F Radiolabeling of Bombesin. Angew. Chem. Int. Ed. 2011; 50: 11117.

Debets et al.; Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition. Chem. Commun. 2010: 46: 97.

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