DBCO-PEG(4)-mal

Chemical name: Dibenzoazacyclooctyne-tetra(ethylene glycol)-maleimide // Synonyms: DBCO-PEG(4)-Maleimide

Product code:RL-2500
CAS No.:1480516-75-3
Formula:C36H42N4O9
Molecular weight:674,74 g/mol
Grouped product items
Qty Packing unit Price SKU
10 mg
$243.00
RL-2500.0010
25 mg
$391.50
RL-2500.0025
100 mg
$864.00
RL-2500.0100
500 mg
$2,700.00
RL-2500.0500
description

Cyclooctyne linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with azides and tetrazines. The maleimide function will form thioethers with free thiols.


This PEG spacer has a length of 30 atoms or 29.7 A.

references

Simon et al.; Facile Double-Functionalization of Designed Ankyrin Repeat Proteins using Click and Thiol Chemistries. Bioconjugate Chem. 2012; 23(2): 279.

Zeng et al.; 64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry. ACS Nano. 2012; 6(6): 5209.

Arumugam et al.; [18F]Azadibenzocyclooctyne ([18F]ADIBO): A biocompatible radioactive labeling synthon for peptides using catalyst free [3+2] cycloaddition. Bioorg. Med. Chem. Lett. 2011; 21: 6987.

Campbell-Verduyn et al.; Strain-Promoted Copper-Free Click Chemistry for 18F Radiolabeling of Bombesin. Angew. Chem. Int. Ed. 2011; 50: 11117.

Debets et al.; Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition. Chem. Commun. 2010: 46: 97.

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