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Chemical name: Tz-benzoyl-TOTA*TFA // Synonyms: N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)-4-(1,2,4,5-tetrazin-3-yl)benzamide trifluoroacetate
|Molecular weight:||404,46*114,02 g/mol|
Tetrazine linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with dienophiles. The amine function can be used to form amid bonds or for alkylation via reductive amination.
Bioorthogonal labelling of biomolecules: new functional handles and ligation methods; Marjoke F. Debets, Jan C. M. van Hest and Floris P. J. T. Rutjes; Org. Biomol. Chem. 2013; 11: 6439-6455; DOI: 10.1039/c3ob41329b.
Biomedical Applications of Tetrazine Cycloadditions; Neal K. Devaraj and Ralph Weissleder; Acc. Chem. Res. 2011; 44(9): 816-827. DOI: 10.1021/ar200037t.
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