HaloTag

Chemical name: 4-((2-(2-((6-chlorohexyl)oxy)ethoxy)ethyl)amino)-4-oxobutanoic acid

Art-No.:RL-3180
Cas-no.:1488363-39-8
Formula:C14H26ClNO5
Molecular weight:323,81 g/mol
Grouped product items
Product variant
100 mg
$128.25
RL-3180.0100
250 mg
$236.25
RL-3180.0250
1 g
$540.00
RL-3180.0001
5 g
$2,160.00
RL-3180.0005
description
This HaloTag linker is an intermediate in the synthesis of HaloTag O2 Tobramycin, a derivative of Tobramycin, which is a single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by Streptomyces tenebrarius. It is soluble in dichloromethane and ethylacetate.

It can be used for a chloroalkane penetration assay (CAPA), which is quantitative, high throughput, and compartment-specific. It can profile the extent of cytosolic penetration with respect to concentration, presence of serum, temperature, and time. It ca n be used to investigate structure'2dpenetration relationships for bioactive stapled peptides and peptides fused to cell-penetrating sequences. Using a cell line where HaloTag is localized to the nucleus, nuclear penetration can be measured quantitatively. A valuable method for measuring and optimizing cell penetration of biotherapeutics can be established with HaloTag.

references
Structure of nebramycin factor 6, a new aminoglycosidic antibiotic. Koch K.F., Rhoades J.A.; Antimicrob. Agents Chemother. (Bethes da). 1970; 10: 309-313.

Welles, J.S., et al.; Toxicol. Appl. Pharmacol. 1972; 22: 332.

Dash, A.K., et al.; Anal. Profiles Drug Subs. Excip. 1996; 24: 579.

Cell Penetration Profiling Using the Chloroalkane Penetration Assay. Leila Peraro, Kirsten L. Deprey, Matthew K. Moser, Zhongju Zou, Haydn L. Ball, Beth Levine, Joshua A. Kritzer; J. Am. Chem. Soc. 2018; 140: 11360'2d11369. DOI: 10.1021/jacs.8b06144.

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