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It can be used for a chloroalkane penetration assay (CAPA), which is quantitative, high throughput, and compartment-specific. It can profile the extent of cytosolic penetration with respect to concentration, presence of serum, temperature, and time. It ca n be used to investigate structure◊'2dpenetration relationships for bioactive stapled peptides and peptides fused to cell-penetrating sequences. Using a cell line where HaloTag is localized to the nucleus, nuclear penetration can be measured quantitatively. A valuable method for measuring and optimizing cell penetration of biotherapeutics can be established with HaloTag.
Welles, J.S., et al.; Toxicol. Appl. Pharmacol. 1972; 22: 332.
Dash, A.K., et al.; Anal. Profiles Drug Subs. Excip. 1996; 24: 579.
Cell Penetration Profiling Using the Chloroalkane Penetration Assay. Leila Peraro, Kirsten L. Deprey, Matthew K. Moser, Zhongju Zou, Haydn L. Ball, Beth Levine, Joshua A. Kritzer; J. Am. Chem. Soc. 2018; 140: 11360◊'2d11369. DOI: 10.1021/jacs.8b06144.
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