Haloalkane Dehalogenase Substrate

Chemical name: 4-((2-(2-((6-chlorohexyl)oxy)ethoxy)ethyl)amino)-4-oxobutanoic acid // Synonyms: Haloalkane Dehalogenase Ligand

Art-No. :RL-3180
CAS-No. :1488363-39-8
Formula :C14H26ClNO5
Molecular weight :323,81 g/mol
Grouped product items
Qty Weight Price SKU
100 mg
$128.25
RL-3180.0100
250 mg
$236.25
RL-3180.0250
1 g
$540.00
RL-3180.0001
5 g
$2,160.00
RL-3180.0005
Safety Data Sheets
description
This chloroalkane linker is a ligand for a specific modified bacterial haloalkane dehalogenase, also known as HaloTag. The linker can be used for the chloroalkane penetration assay (CAPA), a quantitative and compartment-specific cell penetration assay for peptides and other potential biotherapeutics.

Further applications of the HaloTag technology include cellular imaging as well as protein immobilization. Those applications can be accessed via an appropriate modification of the linker's carboxyl terminus, e.g. with an amine-functionalized fluorophore.

references
Bifunctional Mo lecules beyond PROTACs; S. J. Conway; Journal of medicinal chemistry 2020; 63: 2802-2806. doi: https://doi.org/10.1021/acs.jmedchem.0c00293

Cell Penetration Profiling Using the Chloroalkane Penetration Assay; L. Peraro, K. L. Deprey, M. K. Moser, Z. Zou, H. L. Ball, B. Levine and J. A. Kritzer; J Am Chem Soc 2018; 140: 11360-11369. doi: https://doi.org/10.1021/jacs.8b06144

HaloTag technology: a versatile platform for biomedical applications; C. G. England, H. Luo and W. Cai; Bioconjug Chem 2015; 26: 975-86. doi: https://doi.org/10.1021/acs.bioconjchem.5b00191

HaloTag: a novel protein labeling technology for cell imaging and protein analysis; G. V. Los, L. P. Encell, M. G. McDougall, D. D. Hartzell, N. Karassina, C. Zimprich, M. G. Wood, R. Learish, R. F. Ohana, M. Urh, D. Simpson, J. Mendez, K. Zimmerman, P. Otto, G. Vidugiris, J. Zh u, A. Darzins, D. H. Klaubert, R. F. Bulleit and K. V. Wood; ACS Chem Biol 2008; 3: 373-382. doi: https://doi.org/10.1021/cb800025k

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