Chemical name: 2-((9-Fluorenylmethyloxycarbonylamino)ethyl)disulfanyl-(2-aminoethane) hydrochloride // Synonyms: Fmoc-SS-NH2*HCl, (9H-fluoren-9-yl)methyl 2-((2-aminoethyl)disulfanyl)ethylcarbamate hydrochloride

  • Product code:RL-3370
  • CAS No.:2576471-32-2 net
  • Formula:C19H22N2O2S2*HCl
  • Molecular weight:374,52*36,45 g/mol
  • Purity :> 98%

Starting at $144.90

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25 g
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Converting carboxylic groups into amine functions for successive derivatization. The disulfide group allows cleavage of this linker at any later stage by reductive conditions.


Synthesis and evaluation of redox-sensitive gonadotropin-releasing hormone receptor-targeting peptide conjugates; Yuxuan Dai, Na Yue, Chunxia Liu, Xingguang Cai, Xin Su, Xinzhou Bi, Qifei Li, Chengye Li, Wenlong Huang, Hai Qian; Bioorganic Chemistry 2019; 88: 102945. DOI: org/10.1016/j.bioorg.2019.102945.

Tandem Molecular Self Assembly in Liver Cancer Cells; Jie Zhan, Yanbin Cai, Shuangshuang He, Ling Wang, Zhimou Yang; Angew. Chem. Int. Ed. 2018; 57(7): 1813-1816. DOI: org/10.1002/anie.201710237.

Chemoenzymatic Enrichment of Phosphotyrosine Containing Peptides; Shuwei Li, Dexing Zeng; Angew. Chem. Int. Ed. 2007; 46(25): 4751-4753. DOI: org/10.1002/anie.200700633.

Palladium-mediated bioorthogonal conjugation of dual-functionalised nanoparticles and their cellular delivery; Frank Thielbeer, Sunay V. Chankeshwara, Emma M. V. Johansson, Neil Norouzi, Mark Bradley; Chem. Sci. 2013; 4: 425-431. DOI: 10.1039/C2SC20706K.

Disulfide bond as a cleavable linker for molecular self-assembly and hydrogelation; Chunhua Ren, Zhijian Song, Wenting Zheng, Xuemei Chen, Ling Wang, Deling Kong, Zhimou Yang; Chem. Commun. 2011; 47: 1619-1621. DOI: 10.1039/C0CC04135A.

Peptide-Induced AIEgen Self-Assembly: A New Strategy to Realize Highly Sensitive Fluorescent Light-Up Probes. Aitian Han, Huaimin Wang, Ryan T. K. Kwok, Shenglu Ji, Jun Li, Deling Kong, Ben Zhong Tang, Bin Liu, Zhimou Yang, Dan Ding; Anal. Chem. 2016; 88(7): 3872-3878. DOI: org/10.1021/acs.analchem.6b00023.

Disulfide bond reduction-triggered molecular hydrogels of folic acid–Taxol conjugates; Chengbiao Yang, Dongxia Li, Qianqi Feng Zhao, Lianyong Wang, Ling Wang Zhimou Yang; Org. Biomol. Chem. 2013; 11: 6946-6951. DOI: 10.1039/C3OB40969D.

Conjugation of two complementary anti-cancer drugs confers molecular hydrogels as a co-delivery system; Lina Mao, Huaimin Wang, Ming Tan, Lailiang Ou, Deling Kong, Zhimou Yang; Chem. Commun. 2012; 48: 395-397. DOI: 10.1039/C1CC16250K.

Development of Hydrogel TentaGel Shell Core Beads for Ultrahigh Throughput Solution-Phase Screening of Encoded OBOC Combinatorial Small Molecule Libraries; Hyoung Gee Baek, Ruiwu Liu, Kit S. Lam; J. Comb. Chem. 2009; 11(1): 91-102. DOI: org/10.1021/cc800092y.

Covalent Display of Oligosaccharide Arrays in Microtiter Plates. Marian C. Bryan, Fabio Fazio, Hing-Ken Lee, Cheng-Yuan Huang, Aileen Chang, Michael D. Best, Daniel A. Calarese, Ola Blixt, James C. Paulson, Dennis Burton, Ian A. Wilson, Chi-Huey Wong; J. Am. Chem. Soc. 2004; 126(28): 8640-8641.DOI: org/10.1021/ja048433f

A Ratiometric Fluorescent Probe for Thiols Based on a Tetrakis(4-hydroxyphenyl)porphyrin–Coumarin Scaffold. Xiaowei Cao, Weiying Lin, Quanxing Yu; J. Org. Chem. 2011; 76(18): 7423-7430. DOI: org/10.1021/jo201199k

Reduction-sensitive fluorescence enhanced polymeric prodrug nanoparticles for combinational photothermal-chemotherapy. Zhang Y., Yang D., Chen H., Lim W.Q., Phua F.S.Z., An G., Yang P., Zhao Y.; Biomaterials 2018; 163: 14-24. DOI: 10.1016/j.biomaterials.2018.02.023

Glutathione-Responsive Self-Assembled Magnetic Gold Nanowreath for Enhanced Tumor Imaging and Imaging-Guided Photothermal Therapy. Yijing Liu, Zhen Yang, Xiaolin Huang, Guocan Yu, Sheng Wang, Zijian Zhou, Zheyu Shen, Wenpei Fan, Yi Liu, Matthew Davisson, Heather Kalish, Gang Niu, Zhihong Nie, Xiaoyuan Chen; ACS Nano 2018; 12(8): 8129-8137. DOI: org/10.1021/acsnano.8b02980

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