Boc-NH-SS-OpNC

Chemical name: 2-((2-(t-Butyloxycarbonylamino)ethyl)disulfaneyl)ethan-1-yl p-nitrophenylcarbonate // Synonyms: Boc-NH-SS-OPNP, tert-butyl (2-((2-(((4-nitrophenoxy)carbonyl)oxy)ethyl)disulfaneyl)ethyl)carbamate

  • Product code:RL-3520
  • CAS No.:2040301-00-4
  • Formula:C16H22N2O7S2
  • Molecular weight:418.48 g/mol

Starting at $227.50

Grouped product items
Qty Packing unit Price SKU
100 mg
$227.50
RL-3520.0100
250 mg
$455.00
RL-3520.0250
1 g
$1,300.00
RL-3520.1000
description

Boc-protected self-immolative linker for traceless bioconjugation. The p-nitrophenylcarbonate activating group reacts preferably with amine and other nucleophlies.


references

Disulfide-Based Self-Immolative Linkers and Functional Bioconjugates for Biological Applications; Z. Deng, J. Hu and S. Liu; Macromol Rapid Commun 2020; 41: e1900531. https://doi.org/10.1002/marc.201900531

Reduction-Triggered Transformation of Disulfide-Containing Micelles at Chemically Tunable Rates; Z. Deng, S. Yuan, R. X. Xu, H. Liang and S. Liu; Angew Chem Int Ed Engl 2018; 57: 8896-8900. https://doi.org/10.1002/anie.201802909

Growth inhibition of human ovarian carcinoma by a novel AvidinOX-anchored biotinylated camptothecin derivative; O. Minenkova, L. Vesci, R. De Santis, D. Santapaola, R. Cincinelli, L. Musso, S. Dallavalle and G. Giannini; Bioorg Med Chem Lett 2018; 28: 3312-3314. https://doi.org/10.1016/j.bmcl.2018.09.017

Photo- and Reduction-Responsive Polymersomes for Programmed Release of Small and Macromolecular Payloads; Z. Sun, G. Liu, J. Hu and S. Liu; Biomacromolecules 2018; 19: 2071-2081. https://doi.org/10.1021/acs.biomac.8b00253

A biotin-conjugated pyridine-based isatoic anhydride, a selective room temperature RNA-acylating agent for the nucleic acid separation; S. Ursuegui, R. Yougnia, S. Moutin, A. Burr, C. Fossey, T. Cailly, A. Laayoun, A. Laurent and F. Fabis; Org Biomol Chem 2015; 13: 3625-32. https://doi.org/10.1039/c4ob02636e

Water-soluble prodrugs of paclitaxel containing self-immolative disulfide linkers; M. Gund, A. Khanna, N. Dubash, A. Damre, K. S. Singh and A. Satyam; Bioorg Med Chem Lett 2015; 25: 122-7. https://doi.org/10.1016/j.bmcl.2014.10.088

Camptothecin delivery into hepatoma cell line by galactose-appended fluorescent drug delivery system; S. Dongbang, H. M. Jeon, M. H. Lee, W. S. Shin, J. K. Kwon, C. Kang and J. S. Kim; RSC Advances 2014; 4: 18744-18748. https://doi.org/10.1039/c4ra02588a

Mitochondrial thioredoxin-responding off-on fluorescent probe; M. H. Lee, J. H. Han, J. H. Lee, H. G. Choi, C. Kang and J. S. Kim; J Am Chem Soc 2012; 134: 17314-9. https://doi.org/10.1021/ja308446y

A two-photon fluorescent probe for thiols in live cells and tissues; J. H. Lee, C. S. Lim, Y. S. Tian, J. H. Han and B. R. Cho; J Am Chem Soc 2010; 132: 1216-7. https://doi.org/10.1021/ja9090676

Fluorescence imaging of cellular glutathione using a latent rhodamine; M. M. Pires and J. Chmielewski; Org Lett 2008; 10: 837-40. https://doi.org/10.1021/ol702769n

Bulk or large quantity order?

Do you need larger quantities for your development or production?

Do you need further information about this product?

get in contact

Quick contact

Please send me more information about

We found other products you might like!